Cancer stem cell definitions and terminology: the devil is in the details

被引：540

作者：

Valent, Peter ^{[1
,4
]}

Bonnet, Dominique ^{[5
]}

De Maria, Ruggero ^{[8
]}

Lapidot, Tsvee ^{[9
]}

Copland, Mhairi ^{[10
]}

Melo, Junia V. ^{[6
,7
]}

Chomienne, Christine ^{[11
]}

Ishikawa, Fumihiko ^{[15
]}

Schuringa, Jan Jacob ^{[16
]}

Stassi, Giorgio ^{[17
]}

Huntly, Brian ^{[18
,19
]}

Herrmann, Harald ^{[1
,4
]}

Soulier, Jean ^{[12
,13
,14
]}

Roesch, Alexander ^{[20
]}

Schuurhuis, Gerrit Jan ^{[21
]}

Woehrer, Stefan ^{[2
]}

Arock, Michel ^{[22
]}

Zuber, Johannes ^{[3
]}

Cerny-Reiterer, Sabine ^{[1
,4
]}

Johnsen, Hans E. ^{[23
]}

Andreeff, Michael ^{[24
,25
]}

Eaves, Connie ^{[26
]}

机构：

[1] Med Univ Vienna, Dept Internal Med 1, Div Hematol & Hemostaseol, A-1090 Vienna, Austria

[2] Med Univ Vienna, Dept Internal Med 1, Bone Marrow & Stem Cell Transplantat Unit, A-1090 Vienna, Austria

[3] Vienna Bioctr, Res Inst Mol Pathol, A-1030 Vienna, Austria

[4] Ludwig Boltzmann Cluster Oncol, A-1090 Vienna, Austria

[5] Lincolns Inn Fields Labs, Haematopoiet Stem Cell Lab, London Res Inst, London WC2A 3LY, England

[6] Univ London Imperial Coll Sci Technol & Med, London W12 0NN, England

[7] Ctr Canc Biol, Dept Haematol, Adelaide, SA 5000, Australia

[8] Regina Elena Inst Canc Res, I-00144 Rome, Italy

[9] Weizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel

[10] Univ Glasgow, Paul OGorman Leukaemia Res Ctr, Coll Med Vet & Life Sci, Gartnavel Gen Hosp, Glasgow G12 0ZD, Lanark, Scotland

[11] Hop St Louis, Serv Biol Cellulaire, UMR S 940, Inst Univ Hematol, F-75010 Paris, France

[12] Hop St Louis, INSERM, U944, F-75010 Paris, France

[13] Hop St Louis, Haematol Lab, F-75010 Paris, France

[14] Univ Paris Diderot, F-75010 Paris, France

[15] RIKEN RCAI, Res Unit Human Dis Models, Res Ctr Allergy & Immunol, Tsurumi Ku, Yokohama, Kanagawa 2300045, Japan

[16] Univ Groningen, Dept Expt Hematol, Univ Med Ctr Groningen, NL-9713 GZ Groningen, Netherlands

[17] Univ Palermo, Lab Cellular & Mol Pathophysiol, Dept Surg & Oncol Sci, I-90127 Palermo, Italy

[18] Univ Cambridge, Dept Haematol, Cambridge Inst Med Res, Cambridge CB2 0XY, England

[19] Univ Cambridge, Stem Cell Inst, Cambridge CB2 0XY, England

[20] Saarland Univ Hosp, Dept Dermatol, D-66421 Homburg, Germany

[21] Vrije Univ Amsterdam, Dept Hematol, Med Ctr, NL-1081 HV Amsterdam, Netherlands

[22] Ecole Normale Super, LBPA, CNRS, UMR8113, F-94235 Cachan, France

[23] AHSIC Aarhus Univ Hosp, Dept Haematol, Aalborg Hosp Sci & Innovat Ctr, DK-9000 Aalborg, Denmark

[24] Univ Texas MD Anderson Canc Ctr, Dept Leukemia, Houston, TX 77030 USA

[25] Univ Texas MD Anderson Canc Ctr, Dept Stem Cell Transplantat & Cellular Therapy, Houston, TX 77030 USA

[26] British Columbia Canc Agcy, Terry Fox Lab, Vancouver, BC V5Z 1L3, Canada

来源：

NATURE REVIEWS CANCER | 2012年 / 12卷 / 11期

关键词：

CHRONIC MYELOID-LEUKEMIA; IN-VITRO PROPAGATION; INITIATING CELLS; GENE-EXPRESSION; PHENOTYPIC HETEROGENEITY; REPOPULATING CELLS; PERIPHERAL-BLOOD; CLONAL EVOLUTION; MELANOMA-CELLS; IDENTIFICATION;

D O I：

10.1038/nrc3368

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The cancer stem cell (CSC) concept has important therapeutic implications, but its investigation has been hampered both by a lack of consistency in the terms used for these cells and by how they are defined. Evidence of their heterogeneous origins, frequencies and their genomic, as well as their phenotypic and functional, properties has added to the confusion and has fuelled new ideas and controversies. Participants in The Year 2011 Working Conference on CSCs met to review these issues and to propose a conceptual and practical framework for CSC terminology. More precise reporting of the parameters that are used to identify CSCs and to attribute responses to them is also recommended as key to accelerating an understanding of their biology and developing more effective methods for their eradication in patients.

引用

页码：767 / 775

页数：9

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