Immunoglobulin Expression and Its Biological Significance in Cancer Cells

被引：37
作者：
Hu, Duosha [1 ]
Zheng, Hui [1 ]
Liu, Haidan [1 ]
Li, Ming [1 ]
Ren, Wei [1 ]
Liao, Wei [1 ]
Duan, Zhi [1 ]
Li, Lili [1 ]
Cao, Ya [1 ]
机构：
[1] Cent S Univ, Xiangya Sch Med, Canc Res Inst, Changsha 410078, Hunan, Peoples R China
来源：
CELLULAR & MOLECULAR IMMUNOLOGY | 2008年 / 5卷 / 05期
基金：
中国国家自然科学基金; 国家杰出青年科学基金;
关键词：
immunoglobulin; carcinoma; recombination; class switch; signal transduction;
D O I：
10.1038/cmi.2008.39
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
It is generally believed that the expression of a gene is restricted "within the right place and at the right time". This principle has long been considered applicable as well to the expression of immunoglobulin (Ig) lymphocytes of B cell lineage. However, increasing evidence has shown Ig "paradoxically" expressed in malignant tumors of epithelial origin. We reviewed the recent progress in the study of cancer-derived Ig, and also discussed its mechanisms and possible functions, trying to arouse interest and attention to those working in the field of immunology and oncology. Cellular & Molecular Immunology. 2008;5(5):319-324.
引用
收藏
页码：319 / 324
页数：6
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