Impact of sintering temperature on the phase composition and antibacterial properties of silver-doped hydroxyapatite

被引：14
作者：
Dubnika, Arita [1 ]
Loca, Dagnija [1 ]
Reinis, Aigars [2 ]
Kodols, Maris [3 ]
Berzina-Cimdina, Liga [1 ]
机构：
[1] Riga Tech Univ, Rudolfs Cimdins Riga Biomat Innovat & Dev Ctr, LV-1007 Riga, Latvia
[2] Riga Stradins Univ, Dept Biol & Microbiol, LV-1007 Riga, Latvia
[3] Riga Tech Univ, Inst Inorgan Chem, LV-2169 Salaspils, Latvia
来源：
PURE AND APPLIED CHEMISTRY | 2013年 / 85卷 / 02期
关键词：
antimicrobial activity; biomaterials; ceramics; hydroxyapatite; silver; phase transitions; IN-VITRO BIOCOMPATIBILITY; STAPHYLOCOCCUS-EPIDERMIDIS; PSEUDOMONAS-AERUGINOSA; ANTIMICROBIAL ACTIVITY; CALCIUM PHOSPHATES; BIOFILM FORMATION; COATINGS; SUBSTITUTION; RELEASE; BONE;
D O I：
10.1351/PAC-CON-12-08-12
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In the present study, the impact of sintering temperature on the phase composition and antibacterial properties of silver-doped hydroxyapatite (HAp/Ag) samples was investigated. HAp/Ag containing 0.2 and 1.2 % silver was prepared using a modified wet chemical precipitation method. The surface morphology and inner structure of the sintered samples were discussed. X-ray powder diffraction (XRD) and scanning electron microscopy (SEM) studies showed that, after the sintering process, HAp/Ag contained a silver oxide phase, which was not observed in raw materials. Phase composition changes at different sintering temperatures were studied, and it was found that silver oxide undergoes phase changes during the sintering process. In vitro antibacterial properties approved the excellent anti microbial activity of HAp/Ag against the bacterial strains Staphylococcus epidermidis and Pseudomonas aeruginosa. The HAp/Ag sample with 1.2 % silver content, sintered at 1150 degrees C, showed the highest antibacterial activity.
引用
收藏
页码：453 / 462
页数：10
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