The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data

被引：12921

作者：

Cerami, Ethan ^{[1
]}

Gao, Jianjiong ^{[1
]}

Dogrusoz, Ugur ^{[3
]}

Gross, Benjamin E. ^{[1
]}

Sumer, Selcuk Onur ^{[3
]}

Aksoy, Buelent Arman ^{[1
,2
]}

Jacobsen, Anders ^{[1
]}

Byrne, Caitlin J. ^{[1
]}

Heuer, Michael L.

Larsson, Erik ^{[1
]}

Antipin, Yevgeniy ^{[1
]}

Reva, Boris ^{[1
]}

Goldberg, Arthur P. ^{[1
]}

Sander, Chris ^{[1
]}

Schultz, Nikolaus ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Computat Biol Ctr, New York, NY 10021 USA

[2] Triinst Training Program Computat Biol & Med, New York, NY USA

[3] Bilkent Univ, Dept Comp Engn, Ankara, Turkey

来源：

CANCER DISCOVERY | 2012年 / 2卷 / 05期

关键词：

MUTATIONS; NETWORK;

D O I：

10.1158/2159-8290.CD-12-0095

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The cBio Cancer Genomics Portal (http://cbioportal.org) is an open-access resource for interactive exploration of multidimensional cancer genomics data sets, currently providing access to data from more than 5,000 tumor samples from 20 cancer studies. The cBio Cancer Genomics Portal significantly lowers the barriers between complex genomic data and cancer researchers who want rapid, intuitive, and high-quality access to molecular profiles and clinical attributes from large-scale cancer genomics projects and empowers researchers to translate these rich data sets into biologic insights and clinical applications. Cancer Discov; 2(5); 401-4. (c) 2012 AACR.

引用

页码：401 / 404

页数：4

共 15 条

[1]

[Anonymous], DATABASE OXFORD

[2] Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy [J].

Barretina, Jordi ;

Taylor, Barry S. ;

Banerji, Shantanu ;

Ramos, Alexis H. ;

Lagos-Quintana, Mariana ;

DeCarolis, Penelope L. ;

Shah, Kinjal ;

Socci, Nicholas D. ;

Weir, Barbara A. ;

Ho, Alan ;

Chiang, Derek Y. ;

Reva, Boris ;

Mermel, Craig H. ;

Getz, Gad ;

Antipin, Yevgenyi ;

Beroukhim, Rameen ;

Major, John E. ;

Hatton, Charles ;

Nicoletti, Richard ;

Hanna, Megan ;

Sharpe, Ted ;

Fennell, Tim J. ;

Cibulskis, Kristian ;

Onofrio, Robert C. ;

Saito, Tsuyoshi ;

Shukla, Neerav ;

Lau, Christopher ;

Nelander, Sven ;

Silver, Serena J. ;

Sougnez, Carrie ;

Viale, Agnes ;

Winckler, Wendy ;

Maki, Robert G. ;

Garraway, Levi A. ;

Lash, Alex ;

Greulich, Heidi ;

Root, David E. ;

Sellers, William R. ;

Schwartz, Gary K. ;

Antonescu, Cristina R. ;

Lander, Eric S. ;

Varmus, Harold E. ;

Ladanyi, Marc ;

Sander, Chris ;

Meyerson, Matthew ;

Singer, Samuel .

NATURE GENETICS, 2010, 42 (08) :715-U103

[3]

Bateman A, 2004, NUCLEIC ACIDS RES, V32, pD138, DOI [10.1093/nar/gkp985, 10.1093/nar/gkh121, 10.1093/nar/gkr1065]

[4] Integrated genomic analyses of ovarian carcinoma [J].

Bell, D. ;

Berchuck, A. ;

Birrer, M. ;

Chien, J. ;

Cramer, D. W. ;

Dao, F. ;

Dhir, R. ;

DiSaia, P. ;

Gabra, H. ;

Glenn, P. ;

Godwin, A. K. ;

Gross, J. ;

Hartmann, L. ;

Huang, M. ;

Huntsman, D. G. ;

Iacocca, M. ;

Imielinski, M. ;

Kalloger, S. ;

Karlan, B. Y. ;

Levine, D. A. ;

Mills, G. B. ;

Morrison, C. ;

Mutch, D. ;

Olvera, N. ;

Orsulic, S. ;

Park, K. ;

Petrelli, N. ;

Rabeno, B. ;

Rader, J. S. ;

Sikic, B. I. ;

Smith-McCune, K. ;

Sood, A. K. ;

Bowtell, D. ;

Penny, R. ;

Testa, J. R. ;

Chang, K. ;

Dinh, H. H. ;

Drummond, J. A. ;

Fowler, G. ;

Gunaratne, P. ;

Hawes, A. C. ;

Kovar, C. L. ;

Lewis, L. R. ;

Morgan, M. B. ;

Newsham, I. F. ;

Santibanez, J. ;

Reid, J. G. ;

Trevino, L. R. ;

Wu, Y. -Q. ;

Wang, M. .

NATURE, 2011, 474 (7353) :609-615

[5] Pathway Commons, a web resource for biological pathway data [J].

Cerami, Ethan G. ;

Gross, Benjamin E. ;

Demir, Emek ;

Rodchenkov, Igor ;

Babur, Oezguen ;

Anwar, Nadia ;

Schultz, Nikolaus ;

Bader, Gary D. ;

Sander, Chris .

NUCLEIC ACIDS RESEARCH, 2011, 39 :D685-D690

[6] Comprehensive genomic characterization defines human glioblastoma genes and core pathways [J].

Chin, L. ;

Meyerson, M. ;

Aldape, K. ;

Bigner, D. ;

Mikkelsen, T. ;

VandenBerg, S. ;

Kahn, A. ;

Penny, R. ;

Ferguson, M. L. ;

Gerhard, D. S. ;

Getz, G. ;

Brennan, C. ;

Taylor, B. S. ;

Winckler, W. ;

Park, P. ;

Ladanyi, M. ;

Hoadley, K. A. ;

Verhaak, R. G. W. ;

Hayes, D. N. ;

Spellman, Paul T. ;

Absher, D. ;

Weir, B. A. ;

Ding, L. ;

Wheeler, D. ;

Lawrence, M. S. ;

Cibulskis, K. ;

Mardis, E. ;

Zhang, Jinghui ;

Wilson, R. K. ;

Donehower, L. ;

Wheeler, D. A. ;

Purdom, E. ;

Wallis, J. ;

Laird, P. W. ;

Herman, J. G. ;

Schuebel, K. E. ;

Weisenberger, D. J. ;

Baylin, S. B. ;

Schultz, N. ;

Yao, Jun ;

Wiedemeyer, R. ;

Weinstein, J. ;

Sander, C. ;

Gibbs, R. A. ;

Gray, J. ;

Kucherlapati, R. ;

Lander, E. S. ;

Myers, R. M. ;

Perou, C. M. ;

McLendon, Roger .

NATURE, 2008, 455 (7216) :1061-1068

[7] Founder mutations in BRCA1 and BRCA2 genes [J].

Ferla, R. ;

Calo, V. ;

Cascio, S. ;

Rinaldi, G. ;

Badalamenti, G. ;

Carreca, I. ;

Surmacz, E. ;

Coliucci, G. ;

Bazan, V. ;

Russo, A. .

ANNALS OF ONCOLOGY, 2007, 18 :93-98

[8] IntOGen: integration and data mining of multidimensional oncogenomic data [J].

Gundem, Gunes ;

Perez-Llamas, Christian ;

Jene-Sanz, Alba ;

Kedzierska, Anna ;

Islam, Abul ;

Deu-Pons, Jordi ;

Furney, Simon J. ;

Lopez-Bigas, Nuria .

NATURE METHODS, 2010, 7 (02) :92-93

[9] International network of cancer genome projects [J].

Hudson, Thomas J. ;

Anderson, Warwick ;

Aretz, Axel ;

Barker, Anna D. ;

Bell, Cindy ;

Bernabe, Rosa R. ;

Bhan, M. K. ;

Calvo, Fabien ;

Eerola, Iiro ;

Gerhard, Daniela S. ;

Guttmacher, Alan ;

Guyer, Mark ;

Hemsley, Fiona M. ;

Jennings, Jennifer L. ;

Kerr, David ;

Klatt, Peter ;

Kolar, Patrik ;

Kusuda, Jun ;

Lane, David P. ;

Laplace, Frank ;

Lu, Youyong ;

Nettekoven, Gerd ;

Ozenberger, Brad ;

Peterson, Jane ;

Rao, T. S. ;

Remacle, Jacques ;

Schafer, Alan J. ;

Shibata, Tatsuhiro ;

Stratton, Michael R. ;

Vockley, Joseph G. ;

Watanabe, Koichi ;

Yang, Huanming ;

Yuen, Matthew M. F. ;

Knoppers, M. ;

Bobrow, Martin ;

Cambon-Thomsen, Anne ;

Dressler, Lynn G. ;

Dyke, Stephanie O. M. ;

Joly, Yann ;

Kato, Kazuto ;

Kennedy, Karen L. ;

Nicolas, Pilar ;

Parker, Michael J. ;

Rial-Sebbag, Emmanuelle ;

Romeo-Casabona, Carlos M. ;

Shaw, Kenna M. ;

Wallace, Susan ;

Wiesner, Georgia L. ;

Zeps, Nikolajs ;

Lichter, Peter .

NATURE, 2010, 464 (7291) :993-998

[10] Predicting the functional impact of protein mutations: application to cancer genomics [J].

Reva, Boris ;

Antipin, Yevgeniy ;

Sander, Chris .

NUCLEIC ACIDS RESEARCH, 2011, 39 (17) :E118-U85

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