Synthesis and structural optimization of 7-(3,3-disubstituted-1-pyrrolidinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-8-mehtoxy-4-oxo-3-quinolinecarboxylic acids as antibacterial agents

被引：12

作者：

Kitani, H

Kuroda, T

Moriguchi, A

Ao, H

Hirayama, F

Ikeda, Y

Kawakita, T

机构：

[1] Research Laboratories, Yoshitomi Pharmaceut. Indust., Ltd., Chikujo-gun, Fukuoka 871, 955 Koiwai, Yoshitomi-cho

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 05期

关键词：

D O I：

10.1016/S0960-894X(97)00054-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of the titled compounds were synthesized and tested for antibacterial activities in comparison with typical fluoroquinolones. (S)-3-Aminomethyl-3-fluoromethyl derivative (Y-688) was confirmed to be optimal because ofbeing most active especially against Gram-positive bacteria including fluoroquinolone-resistant strains and showing high photostability. (C) 1997 Elsevier Science Ltd.

引用

页码：515 / 520

页数：6

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