The Impairment of Blood-Brain Barrier in Alzheimer's Disease: Challenges and Opportunities with Stem Cells

被引：8

作者：

Lopez-Ornelas, Adolfo ^{[1
,2
]}

Jimenez, Adriana ^{[1
]}

Perez-Sanchez, Gilberto ^{[3
]}

Rodriguez-Perez, Citlali Ekaterina ^{[4
]}

Corzo-Cruz, Alejandro ^{[5
]}

Velasco, Ivan ^{[6
,7
]}

Estudillo, Enrique ^{[7
]}

机构：

[1] Hosp Juarez Mexico, Div Invest, Mexico City 07760, DF, Mexico

[2] Hosp Fed Referencia, Hosp Nacl Homeopat, Mexico City 06800, DF, Mexico

[3] Inst Nacl Psiquiatria Ramon Fuente Muniz, Lab Psicoinmunol, Calzada Mexico Xochimilco 101, Mexico City 14370, DF, Mexico

[4] Inst Nacl Neurol & Neurocirug, Lab Neurofarmacol Mol & Nanotecnol, Mexico City 14269, DF, Mexico

[5] Secretaria Def Nacl, Lab Traslac, Escuela Mil Graduados Sanidad, Batalla Celaya 202, Mexico City 11200, DF, Mexico

[6] Univ Nacl Autonoma Mexico, Inst Fisiol Celular Neurociencias, Mexico City 04510, DF, Mexico

[7] Inst Nacl Neurol & Neurocirugia Manuel Velasco Su, Lab Reprogramac Celular, Mexico City 14269, DF, Mexico

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 17期

关键词：

Alzheimer's disease; blood-brain barrier; MSCs; NSCs; AMYLOID-BETA-PEPTIDE; A-BETA; INFLAMMATORY MECHANISMS; IMPROVE MEMORY; SOMATIC-CELLS; MOUSE MODELS; TAU LEVELS; PROTEIN; PHOSPHORYLATION; PRECURSOR;

D O I：

10.3390/ijms231710136

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Alzheimer's disease (AD) is the most common neurodegenerative disorder and its prevalence is increasing. Nowadays, very few drugs effectively reduce AD symptoms and thus, a better understanding of its pathophysiology is vital to design new effective schemes. Presymptomatic neuronal damage caused by the accumulation of Amyloid beta peptide and Tau protein abnormalities remains a challenge, despite recent efforts in drug development. Importantly, therapeutic targets, biomarkers, and diagnostic techniques have emerged to detect and treat AD. Of note, the compromised blood-brain barrier (BBB) and peripheral inflammation in AD are becoming more evident, being harmful factors that contribute to the development of the disease. Perspectives from different pre-clinical and clinical studies link peripheral inflammation with the onset and progression of AD. This review aims to analyze the main factors and the contribution of impaired BBB in AD development. Additionally, we describe the potential therapeutic strategies using stem cells for AD treatment.

引用

页数：17

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