Palladium-Catalyzed Stereoselective Formation of Substituted Allylic Thioethers and Sulfones

被引：79

作者：

Gomez, Jose Enrique ^{[1
]}

Guo, Wusheng ^{[1
]}

Kleij, W. ^{[1
,2
]}

机构：

[1] Barcelona Inst Sci & Technol, Inst Chem Res Catalonia ICIQ, Ave Paisos Catalans 16, Tarragona 43007, Spain

[2] Catalan Inst Res & Adv Studies ICREA, Pg Lluis Co 23, Barcelona 08010, Spain

来源：

ORGANIC LETTERS | 2016年 / 18卷 / 23期

关键词：

BAYLIS-HILLMAN ACETATES; ASYMMETRIC-SYNTHESIS; HIGHLY EFFICIENT; BOND FORMATION; CARBON-MONOXIDE; C-S; SULFIDES; ALLENES; HYDROTHIOLATION; THIOLS;

D O I：

10.1021/acs.orglett.6b02981

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general method is reported for the stereo selective preparation of highly functionalized allylic thioethers. This protocol is based on a Pd-catalyzed thiolation of modular vinyl cyclic carbonate substrates and features high (Z) selectivity, good yields, minimal waste, ample product scope, and operational simplicity. A one-pot strategy was used for the stereoselective formation of pharma-relevant allylic sulfones derived from their in situ prepared thioether precursors.

引用

页码：6042 / 6045

页数：4

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