A possible role of vimentin on the cell surface for the activation of latent transforming growth factor-β

被引：8

作者：

Nishida, Yasutake ^{[1
]}

Shibata, Kenji ^{[1
]}

Yamasaki, Motoo ^{[1
]}

Sato, Yasufumi ^{[2
]}

Abe, Mayumi ^{[2
]}

机构：

[1] Kyowa Hakko Kirin Co Ltd, Div Res, Innovat Drug Res Labs, Tokyo 1948533, Japan

[2] Tohoku Univ, Inst Dev Aging & Canc, Dept Vasc Biol, Sendai, Miyagi 9808575, Japan

来源：

FEBS LETTERS | 2009年 / 583卷 / 02期

关键词：

Latent TGF-beta activation; Vimentin; LAP fragment; Avidin-biotin affinity; Proteolysis; SMOOTH-MUSCLE-CELLS; TGF-BETA; SYNOVIAL-FLUID; BINDING;

D O I：

10.1016/j.febslet.2008.12.051

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Latent TGF-beta (LTGF-beta) has to be converted to active TGF-beta for its activities. Previously, we reported that certain fragments of latency associated peptide (LAP) augmented LTGF-beta activation via increase in binding of LTGF-beta to the endothelial cell (EC) surface followed by cell-associated proteolysis. By searching for EC membrane proteins crosslinked with the LAP fragment, we identified the molecule bound to LAP fragment as vimentin. Moreover, the LAP fragment-induced LTGF-beta activation was attenuated by anti-vimentin antibody. These results indicate that binding of the LAP fragment to vimentin on the cell surface is indispensable for LTGF-beta activation by the LAP fragment.

引用

页码：308 / 312

页数：5

共 50 条

[21] Role of transforming growth factor-β and its latent form binding protein in pseudoexfoliation syndrome
Schlötzer-Schrehardt, U
Küchle, M
Rummelt, C
Naumann, GOH
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 1999, 40 (04) : S278 - S278
[22] Augmented binding and activation of latent transforming growth factor-β by a tryptic fragment of latency associated peptide
Abe, M
Oda, N
Sato, Y
Shibata, K
Yamasaki, M
ENDOTHELIUM-NEW YORK, 2002, 9 (01): : 25 - 36
[23] Participation of thrombospondin-1 in the activation of latent transforming growth factor-β in malignant glioma cells
Sasaki, A
Naganuma, H
Satoh, E
Kawataki, T
Amagasaki, K
Nukui, H
NEUROLOGIA MEDICO-CHIRURGICA, 2001, 41 (05) : 253 - 258
[24] In vitro and in vivo evidence for shear-induced activation of latent transforming growth factor-β1
Ahamed, Jasimuddin
Burg, Nathalie
Yoshinaga, Keiji
Janczak, Christin A.
Rifkin, Daniel B.
Coller, Barry S.
BLOOD, 2008, 112 (09) : 3650 - 3660
[25] Participation of thrombospondin-1 in the activation of latent transforming growth factor-β in malignant glioma cells
Saya, H
NEUROLOGIA MEDICO-CHIRURGICA, 2001, 41 (05): : 258 - 259
[26] The role of transforming growth factor-β in transplant rejection
Hutchinson, IV
TRANSPLANTATION PROCEEDINGS, 1999, 31 (7A) : 9S - 13S
[27] Role of transforming growth factor-β in hematologic malignancies
Dong, Mei
Blobe, Gerard C.
BLOOD, 2006, 107 (12) : 4589 - 4596
[28] Transforming growth factor-β and its role in asthma
Duvernelle, C
Freund, V
Frossard, N
PULMONARY PHARMACOLOGY & THERAPEUTICS, 2003, 16 (04) : 181 - 196
[29] Role of transforming growth factor-β signaling in cancer
de Caestecker, MP
Piek, E
Roberts, AB
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2000, 92 (17): : 1388 - 1402
[30] The role of transforming growth factor-β in carcinogenesis -: Reply
Gleave, M
Monia, BP
NATURE REVIEWS CANCER, 2005, 5 (12) : 995 - 995

← 1 2 3 4 5 →