Dihydroartemisinin induces autophagy by suppressing NF-κB activation

被引：85

作者：

Hu, Wei ^{[1
]}

Chen, Sang-Sang ^{[1
]}

Zhang, Jia-Li ^{[1
]}

Lou, Xiao-E ^{[1
]}

Zhou, Hui-Jun ^{[1
]}

机构：

[1] Zhejiang Univ, Inst Pharmacol & Toxicol, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China

来源：

CANCER LETTERS | 2014年 / 343卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Dihydroartemisinin; Autophagy; NF-kappa B; Translocation; ROS; CANCER-THERAPY RESISTANCE; TUMOR-CELL LINES; TRANSCRIPTION FACTOR; IN-VITRO; ANTIMALARIAL-DRUG; OXIDATIVE STRESS; DEATH; APOPTOSIS; ARTEMISININ; PROTEINS;

D O I：

10.1016/j.canlet.2013.09.035

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Nuclear factor-kappa B (NF-kappa B) and autophagy are two major regulators involved in both tumor initiation and progression. However, the association between these two signaling pathways still remains obscure. In this work, we demonstrate that dihydroartemisinin (DNA) stimulates the induction of autophagy in several cancer cell lines through repression of NF-kappa B activity. We also show that inhibiting NF-kappa B results in an accumulation of reactive oxygen species (ROS), which participate in the stimulation of autophagy. These findings present a pathway by which DHA promotes autophagy in cancer cells and provide evidence for the DHA-induced sensitization effect of some chemotherapeutics. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：239 / 248

页数：10

共 48 条

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