CXCL13 is a biomarker of inflammation in multiple sclerosis, neuromyelitis optica, and other neurological conditions

被引：93
作者：
Alvarez, Enrique [1 ]
Piccio, Laura [1 ]
Mikesell, Robert J. [1 ]
Klawiter, Eric C. [1 ,2 ]
Parks, Becky J. [1 ]
Naismith, Robert T. [1 ]
Cross, Anne H. [1 ]
机构：
[1] Washington Univ, Dept Neurol, St Louis, MO 63110 USA
[2] Harvard Univ, Sch Med, Dept Neurol, Massachusetts Gen Hosp, Boston, MA 02115 USA
来源：
MULTIPLE SCLEROSIS JOURNAL | 2013年 / 19卷 / 09期
基金：
美国国家卫生研究院;
关键词：
Multiple sclerosis; neuromyelitis optica; CXCL13; neuroinflammation; neurofilament; myelin basic protein; biomarker; RITUXIMAB; NMO;
D O I：
10.1177/1352458512473362
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
CXCL13, a B-cell chemokine, has been proposed as a biomarker in a variety of conditions, some of which can mimic multiple sclerosis and can have very high levels. In this case-control study, cerebrospinal fluid (CSF) CXCL13 was elevated in multiple sclerosis, neuromyelitis optica and other inflammatory neurological controls compared with noninflammatory controls. Levels did not differentiate disease groups. For all subjects taken together, CSF CXCL13 correlated with CSF WBC, oligoclonal band numbers, CSF protein, EDSS, and neurofilament levels. In subgroup analyses, CSF CXCL13 correlated with CSF WBC in neuromyelitis optica and IgG index in multiple sclerosis. Additionally, serum CXCL13 was elevated in neuromyelitis optica.
引用
收藏
页码：1204 / 1208
页数：5
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