Immunochemotherapy against colon cancer by gene transfer of interleukin-12 in combination with oxaliplatin

被引：12
作者：
Hernandez-Alcoceba, Ruben [1 ]
Berraondo, Pedro [1 ]
机构：
[1] Univ Navarra, Div Gene Therapy & Hepatol, CIMA, Fdn Appl Med Res, E-31080 Pamplona, Spain
来源：
ONCOIMMUNOLOGY | 2012年 / 1卷 / 01期
关键词：
interleukin-12; oxaliplatin; colorectal cancer; liver; adenovirus; SUPPRESSOR-CELLS; IMMUNE-SYSTEM; EXPRESSION;
D O I：
10.4161/onci.1.1.17930
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Using a murine model of liver metastases, we found that oxaliplatin can enhance the immunostimulatory effect of interleukin-12 delivered by an adenoviral vector. A shift toward a favorable immune microenvironment was observed in tumors, with a relative increase in CD8(+) T cells vs. T regulatory and myeloid-derived suppressor cells.
引用
收藏
页码：97 / 99
页数：3
相关论文
共 50 条
[41]   Novel strategies exploiting interleukin-12 in cancer immunotherapy [J].
Cirella, Assunta ;
Luri-Rey, Carlos ;
Trani, Claudia Augusta Di ;
Teijeira, Alvaro ;
Olivera, Irene ;
Bolanos, Elixabet ;
Castanon, Eduardo ;
Palencia, Belen ;
Brocco, Davide ;
Fernandez-Sendin, Myriam ;
Aranda, Fernando ;
Berraondo, Pedro ;
Melero, Ignacio .
PHARMACOLOGY & THERAPEUTICS, 2022, 239
[42]   Serum interleukin-12 levels in patients with gastric cancer [J].
Murakami, S ;
Okubo, K ;
Tsuji, Y ;
Sakata, H ;
Hamada, S ;
Hirayama, R .
SURGERY TODAY, 2004, 34 (12) :1014-1019
[43]   Oxaliplatin and Infliximab Combination Synergizes in Inducing Colon Cancer Regression [J].
Li, Wenya ;
Xu, Jian ;
Zhao, Jian ;
Zhang, Rui .
MEDICAL SCIENCE MONITOR, 2017, 23 :780-789
[44]   Treatment of disseminated ovarian cancer using nonviral interleukin-12 gene therapy delivered intraperitoneally [J].
Fewell, Jason G. ;
Matar, Majed M. ;
Rice, Jennifer S. ;
Brunhoeber, Elaine ;
Slobodkin, Gregory ;
Pence, Casey ;
Worker, Miranda ;
Lewis, Danny H. ;
Anwer, Khursheed .
JOURNAL OF GENE MEDICINE, 2009, 11 (08) :718-728
[45]   Localized Nano-mediated Interleukin-12 Gene Therapy: Promising Candidate for Cancer Immunotherapeutics [J].
Venkatas, Jeaneen ;
Singh, Moganavelli .
CURRENT CANCER DRUG TARGETS, 2022, 22 (10) :825-842
[46]   Dose and Sequence Dependent Synergism from the Combination of Oxaliplatin with Emetine and Patulin Against Colorectal Cancer [J].
Alam, Md Nur ;
Yu, Jun Q. ;
Beale, Philip ;
Huq, Fazlul .
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2020, 20 (02) :264-273
[47]   The potential therapeutic effect of melatonin in oxaliplatin combination therapy against chemoresistant colorectal cancer cells [J].
Dehghanzad, Masoumeh ;
Mohammadi, Mohammad ;
Nejati, Mohaddeseh ;
Pouremamali, Farhad ;
Maroufi, Nazila Fathi ;
Akbarzadeh, Maryam ;
Samadi, Naser ;
Nouri, Mohammad .
MOLECULAR BIOLOGY REPORTS, 2024, 51 (01)
[48]   The role of interleukin-2, interleukin-12, and dendritic cells in cancer therapy [J].
Lotze, MT ;
Hellerstedt, B ;
Stolinski, L ;
Tueting, T ;
Wilson, C ;
Kinzler, D ;
Vu, H ;
Rubin, JT ;
Storkus, W ;
Tahara, H ;
Elder, E ;
Whiteside, T .
CANCER JOURNAL FROM SCIENTIFIC AMERICAN, 1997, 3 :S109-S114
[49]   Combination of Lappaconitine and Oxaliplatin against Lung Cancer In Vitro [J].
Xu, Meng ;
Sheng, Lianghe ;
Wang, Liang ;
Zhao, Jianfu .
LATIN AMERICAN JOURNAL OF PHARMACY, 2013, 32 (10) :1433-1438
[50]   Sterile protection of monkeys against malaria after administration of interleukin-12 [J].
Hoffman, SL ;
Crutcher, JM ;
Puri, SK ;
Ansari, AA ;
Villinger, F ;
Franke, ED ;
Singh, PP ;
Finkelman, F ;
Gately, ML ;
Dutta, GP ;
Sedegah, M .
NATURE MEDICINE, 1997, 3 (01) :80-83
12345