Immunochemotherapy against colon cancer by gene transfer of interleukin-12 in combination with oxaliplatin

被引：12

作者：

Hernandez-Alcoceba, Ruben ^{[1
]}

Berraondo, Pedro ^{[1
]}

机构：

[1] Univ Navarra, Div Gene Therapy & Hepatol, CIMA, Fdn Appl Med Res, E-31080 Pamplona, Spain

来源：

ONCOIMMUNOLOGY | 2012年 / 1卷 / 01期

关键词：

interleukin-12; oxaliplatin; colorectal cancer; liver; adenovirus; SUPPRESSOR-CELLS; IMMUNE-SYSTEM; EXPRESSION;

D O I：

10.4161/onci.1.1.17930

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Using a murine model of liver metastases, we found that oxaliplatin can enhance the immunostimulatory effect of interleukin-12 delivered by an adenoviral vector. A shift toward a favorable immune microenvironment was observed in tumors, with a relative increase in CD8(+) T cells vs. T regulatory and myeloid-derived suppressor cells.

引用

页码：97 / 99

页数：3

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