Immunochemotherapy against colon cancer by gene transfer of interleukin-12 in combination with oxaliplatin

被引：12
作者：
Hernandez-Alcoceba, Ruben [1 ]
Berraondo, Pedro [1 ]
机构：
[1] Univ Navarra, Div Gene Therapy & Hepatol, CIMA, Fdn Appl Med Res, E-31080 Pamplona, Spain
来源：
ONCOIMMUNOLOGY | 2012年 / 1卷 / 01期
关键词：
interleukin-12; oxaliplatin; colorectal cancer; liver; adenovirus; SUPPRESSOR-CELLS; IMMUNE-SYSTEM; EXPRESSION;
D O I：
10.4161/onci.1.1.17930
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Using a murine model of liver metastases, we found that oxaliplatin can enhance the immunostimulatory effect of interleukin-12 delivered by an adenoviral vector. A shift toward a favorable immune microenvironment was observed in tumors, with a relative increase in CD8(+) T cells vs. T regulatory and myeloid-derived suppressor cells.
引用
收藏
页码：97 / 99
页数：3
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