Conditionally immortalized cell lines with differentiated functions established from temperature-sensitive T-antigen transgenic mice

被引：58

作者：

Obinata, M ^{[1
]}

机构：

[1] TOHOKU UNIV, INST DEV AGEING & CANC, DEPT CELL BIOL, AOBA KU, SENDAI, MIYAGI 9807, JAPAN

来源：

GENES TO CELLS | 1997年 / 2卷 / 04期

关键词：

D O I：

10.1046/j.1365-2443.1997.1160314.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A variety of cell lines with differentiated functions are required to study tissue functions at cellular and molecular levels. Using transgenic mice harbouring ubiquitously expressing the temperature-sensitive T-antigen (ts T-antigen) gene of simian virus 40 (SV40), many cell lines were generated. The properties of these established lines suggested that their growth was dependent on T-antigen, and that they retained some of the differentiated functions of each particular tissue. A possible use of these cell lines for tissue functions in vitro is discussed.

引用

页码：235 / 244

页数：10

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