Conditionally immortalized cell lines with differentiated functions established from temperature-sensitive T-antigen transgenic mice

被引：58

作者：

Obinata, M ^{[1
]}

机构：

[1] TOHOKU UNIV, INST DEV AGEING & CANC, DEPT CELL BIOL, AOBA KU, SENDAI, MIYAGI 9807, JAPAN

来源：

GENES TO CELLS | 1997年 / 2卷 / 04期

关键词：

D O I：

10.1046/j.1365-2443.1997.1160314.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A variety of cell lines with differentiated functions are required to study tissue functions at cellular and molecular levels. Using transgenic mice harbouring ubiquitously expressing the temperature-sensitive T-antigen (ts T-antigen) gene of simian virus 40 (SV40), many cell lines were generated. The properties of these established lines suggested that their growth was dependent on T-antigen, and that they retained some of the differentiated functions of each particular tissue. A possible use of these cell lines for tissue functions in vitro is discussed.

引用

页码：235 / 244

页数：10

共 50 条

[21] Establishment of tsA58 transgenic rats as a source of conditionally immortalized cell lines with differentiated functions [J].

Takahashi, T .

EXPERIMENTAL ANIMALS, 2002, 51 (02) :113-118

[22] Characterization and application of a gastric surface mucous cell line GSM06 established from temperature-sensitive simian virus 40 large T-antigen transgenic mice [J].

Tabuchi, Y .

JAPANESE JOURNAL OF PHARMACOLOGY, 2001, 85 (02) :117-123

[23] ESTABLISHMENT OF GASTRIC SURFACE MUCOUS CELL-LINES FROM TRANSGENIC MICE HARBORING TEMPERATURE-SENSITIVE SIMIAN-VIRUS-40 LARGE T-ANTIGEN GENE [J].

SUGIYAMA, N ;

TABUCHI, Y ;

HORIUCHI, T ;

OBINATA, M ;

FURUSAWA, M .

EXPERIMENTAL CELL RESEARCH, 1993, 209 (02) :382-387

[24] DIFFERENTIATED MAMMALIAN-CELL LINES IMMORTALIZED BY TEMPERATURE-SENSITIVE TUMOR-VIRUSES [J].

CHOU, JY .

MOLECULAR ENDOCRINOLOGY, 1989, 3 (10) :1511-1514

[25] CHARACTERIZATION OF IMMORTALIZED HUMAN CORNEAL EPITHELIAL-CELLS TRANSFECTED WITH A TEMPERATURE-SENSITIVE T-ANTIGEN [J].

OKAMOTO, S ;

KOSAKU, K ;

SUNDARRAJ, N ;

HASSELL, JR ;

PIPAS, M ;

KAO, WWY .

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 1995, 36 (04) :S608-S608

[26] Establishment of vasopressin-responsive early proximal tubular cell lines derived from transgenic mice harboring temperature-sensitive simian virus 40 large T-antigen gene [J].

Takeda, M ;

Hosoyamada, M ;

Shirato, I ;

Obinata, M ;

Suzuki, M ;

Endou, H .

BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL, 1995, 37 (03) :507-515

[27] Conditionally immortalized human podocyte cell lines established from urine [J].

Sakairi, Toru ;

Abe, Yoshifusa ;

Kajiyama, Hiroshi ;

Bartlett, Linda D. ;

Howard, Lilian V. ;

Jat, Parmijit S. ;

Kopp, Jeffrey B. .

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2010, 298 (03) :F557-F567

[28] CELL TYPE-SPECIFIC EXPRESSION OF JC-VIRUS T-ANTIGEN IN PRIMARY AND ESTABLISHED CELL-LINES FROM TRANSGENIC MICE [J].

BEGGS, AH ;

MINER, JH ;

SCANGOS, GA .

JOURNAL OF GENERAL VIROLOGY, 1990, 71 :151-164

[29] Functional characterization of a conditionally immortalized mouse epididymis caput epithelial cell line MEPC5 using temperature-sensitive simian virus 40 large T-antigen [J].

Tabuchi, Y ;

Toyama, Y ;

Toshimor, K ;

Komiyama, M ;

Mori, C ;

Kondo, T .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 329 (03) :812-823

[30] GENERATION AND CHARACTERIZATION OF ESTABLISHED LUNG-CELL LINES FROM TRANSGENIC MICE HARBORING THE SV40 LARGE T-ANTIGEN [J].

WIKENHEISER, KA ;

CLARK, JC ;

OIE, HK ;

WHITSETT, JA .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1993, 147 (04) :A51-A51

← 1 2 3 4 5 →