Uroguanylin Improves Leptin Responsiveness in Diet-Induced Obese Mice

被引：9

作者：

Folgueira, Cintia ^{[1
,2
,3
]}

Beiroa, Daniel ^{[1
,3
]}

Jesus Gonzalez-Rellan, Maria ^{[1
,3
]}

Porteiro, Begona ^{[1
,3
]}

Milbank, Edward ^{[1
]}

Castelao, Cecilia ^{[2
,3
]}

Garcia-Palacios, Maria ^{[2
,4
]}

Casanueva, Felipe F. ^{[3
,5
]}

Lopez, Miguel ^{[1
,3
]}

Dieguez, Carlos ^{[1
,3
]}

Seoane, Luisa M. ^{[2
,3
]}

Nogueiras, Ruben ^{[1
,3
]}

机构：

[1] Univ Santiago de Compostela, Dept Physiol, CIMUS, Inst Invest Sanitaria, Santiago De Compostela 15782, Spain

[2] Complejo Hosp Univ Santiago de Compostela CHUS SE, Inst Invest Sanitaria Santiago de Compostela IDIS, Grp Fisiopatol Endocrina, Santiago De Compostela 15706, Spain

[3] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Santiago De Compostela 15706, Spain

[4] Univ Santiago de Compostela, Dept Pediat Surg, Santiago De Compostela 15706, Spain

[5] Univ Santiago de Compostela, Lab Endocrinol Mol & Celular, Santiago De Compostela 15706, Spain

来源：

NUTRIENTS | 2019年 / 11卷 / 04期

关键词：

uroguanylin; leptin; food intake; body weight; hypothalamus; BODY-WEIGHT; HORMONE; RESISTANCE; ENERGY; AXIS; INTERSECTION; EXPRESSION; GUANYLIN; PEPTIDE; INSULIN;

D O I：

10.3390/nu11040752

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The gastrointestinal-brain axis is a key mediator of the body weight and energy homeostasis regulation. Uroguanylin (UGN) has been recently proposed to be a part of this gut-brain axis regulating food intake, body weight and energy expenditure. Expression of UGN is regulated by the nutritional status and dependent on leptin levels. However, the exact molecular mechanisms underlying this UGN-leptin metabolic regulation at a hypothalamic level still remains unclear. Using leptin resistant diet-induced obese (DIO) mice, we aimed to determine whether UGN could improve hypothalamic leptin sensitivity. The present work demonstrates that the central co-administration of UGN and leptin potentiates leptin's ability to decrease the food intake and body weight in DIO mice, and that UGN activates the hypothalamic signal transducer and activator of transcription 3 (STAT3) and phosphatidylinositide 3-kinases (PI3K) pathways. At a functional level, the blockade of PI3K, but not STAT3, blunted UGN-mediated leptin responsiveness in DIO mice. Overall, these findings indicate that UGN improves leptin sensitivity in DIO mice.

引用

页数：13

共 41 条

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