Thorectandrols C, D, and E, new sesterterpenes from the marine sponge Thorectandra sp.

被引：26

作者：

Charan, RD ^{[1
]}

McKee, TC ^{[1
]}

Boyd, MR ^{[1
]}

机构：

[1] NCI, Canc Res Ctr, Mol Targets Drug Discovery Program, Ft Detrick, MD 21702 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2002年 / 65卷 / 04期

关键词：

D O I：

10.1021/np010439k

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Extracts of the marine sponge Thorectandra sp. have been found to contain three new sesterterpenes, thorectandrols C (4), D (5), and E (6), together with the known compounds luffarin R (7), luffarin V (8), and palauolide (9). The structures were determined by extensive NMR spectral data analysis. Their relative stereochemistry was defined using NOE correlations and coupling constants, while CD data were used to suggest their absolute stereochemistry. Cytotoxicity data for compounds 4-9 as well as the previously reported compounds thorectandrols A and B and palauolol (1-3) against six or more human tumor cell lines are also reported.

引用

页码：492 / 495

页数：4

共 50 条

[41] A new lipid from an Australian marine sponge, Callyspongia sp. [J].

Urban, S ;

Capon, RJ .

LIPIDS, 1997, 32 (06) :675-677

[42] New bioactive polyacetylenes from the marine sponge Petrosia sp. [J].

Kim, JS ;

Im, KS ;

Jung, JH ;

Kim, YL ;

Kim, J ;

Shim, CJ ;

Lee, CO .

TETRAHEDRON, 1998, 54 (13) :3151-3158

[43] New bioactive alkaloids from the marine sponge Stylissa sp. [J].

Fouad, Mostafa A. ;

Debbab, Abdessamad ;

Wray, Victor ;

Mueller, Werner E. G. ;

Proksch, Peter .

TETRAHEDRON, 2012, 68 (49) :10176-10179

[44] New cytotoxic metabolites from a marine sponge Homaxinella sp. [J].

Mansoor, TA ;

Hong, J ;

Lee, CO ;

Sim, CJ ;

Im, KS ;

Lee, DS ;

Jung, JH .

JOURNAL OF NATURAL PRODUCTS, 2004, 67 (04) :721-724

[45] A new manzamine congener from marine sponge Amphimedon sp. [J].

Tsuda, M ;

Watanabe, D ;

Kobayashi, J .

HETEROCYCLES, 1999, 50 (01) :485-488

[46] Two new diketopiperazines from the marine sponge Dysidea sp. [J].

Lei, Yu ;

Liao, Xiao-Jian ;

Xing, Xi-Wen ;

Xu, Shi-Hai ;

Zhao, Bing-Xin .

NATURAL PRODUCT RESEARCH, 2024,

[47] New Bioactive Polyacetylenes from the Marine Sponge Petrosia sp. [J].

Liu, Xin-Lian ;

Ding, Ya-Fang ;

Wang, Shu-Ping ;

Liu, Li ;

Wang, Jie ;

Yang, Fan .

CHEMISTRY & BIODIVERSITY, 2022, 19 (06)

[48] New Cerebrosides from a Marine Sponge Haliclona (Reniera) sp. [J].

Park, Taeseong ;

Mansoor, Tayyab Ahmad ;

Shinde, Pramod Bapurao ;

Bao, Baoquan ;

Hong, Jongki ;

Jung, Jee Hyung .

CHEMICAL & PHARMACEUTICAL BULLETIN, 2009, 57 (01) :106-111

[49] New jaspamide derivatives from the marine sponge Jaspis sp. [J].

Ebada, S. ;

Lin, W. ;

Deng, Z. ;

de Voogd, N. J. ;

Proksch, P. .

PLANTA MEDICA, 2009, 75 (09) :967-968

[50] New Sterol Derivatives from the Marine Sponge Xestospongia sp. [J].

Cheng, Zhongbin ;

Liu, Dong ;

de Voogd, Nicole J. ;

Proksch, Peter ;

Lin, Wenhan .

HELVETICA CHIMICA ACTA, 2016, 99 (08) :588-596

← 1 2 3 4 5 →