Highly Pathogenic Avian Influenza A(H5N1) Mutants Transmissible by Air Are Susceptible to Human and Animal Neutralizing Antibodies

被引：6
|
作者：
Du, Lanying [1 ]
Li, Ye [1 ]
Zhao, Guangyu [2 ]
Wang, Lili [1 ]
Zou, Peng [1 ]
Lu, Lu [3 ,4 ,5 ]
Zhou, Yusen [2 ]
Jiang, Shibo [1 ,3 ,4 ,5 ]
机构：
[1] New York Blood Ctr, Lindsley F Kimball Res Inst, New York, NY 10021 USA
[2] Fudan Univ, Shanghai Med Coll, State Key Lab Pathogen & Biosecur, Beijing Inst Microbiol & Epidemiol, Shanghai, Peoples R China
[3] Fudan Univ, Shanghai Med Coll, Key Lab Med Mol Virol, Minist Educ, Shanghai, Peoples R China
[4] Fudan Univ, Shanghai Med Coll, Key Lab Med Mol Virol, Minist Hlth, Shanghai, Peoples R China
[5] Fudan Univ, Shanghai Med Coll, Inst Med Microbiol, Shanghai, Peoples R China
来源：
JOURNAL OF INFECTIOUS DISEASES | 2013年 / 208卷 / 08期
基金：
美国国家卫生研究院;
关键词：
Patient serum specimens; Neutralizing antibodies; H5N1 influenza virus; Air-transmissibility; VIRUS;
D O I：
10.1093/infdis/jit323
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A laboratory-generated reassortant H5 hemagglutinin (HA)/influenza A(H1N1) strain containing 4 mutations in influenza A(H5N1) HA has become transmissible by air among mammals. Here, we constructed 15 influenza A(H5N1) pseudoviruses containing a single mutation or a combination of mutations and showed that the pseudoviruses were susceptible to neutralizing antibodies from patients with influenza A (H5N1) infection and from mice immunized with a vaccine containing the conserved HA1 sequence of influenza A (H5N1). These results indicate that antibodies in patients currently infected by influenza A(H5N1) and antibodies induced by vaccines containing conserved sequences in HA1 of wild-type influenza A(H5N1) are highly effective in cross-neutralizing future influenza A(H5N1) mutants with airborne transmissibility, suggesting that human influenza pandemics caused by these influenza A(H5N1) variants can be prevented.
引用
收藏
页码：1315 / 1319
页数：5
相关论文
共 50 条
  • [41] Use of GFP-expressing influenza viruses for the detection of influenza virus A/H5N1 neutralizing antibodies
    Rimmelzwaan, Guus F.
    Verburgh, R. Joyce
    Nieuwkoop, Nella J.
    Bestebroer, Theo M.
    Fouchier, Ron A. M.
    Osterhaus, Albert D. M. E.
    VACCINE, 2011, 29 (18) : 3424 - 3430
  • [42] Transatlantic spread of highly pathogenic avian influenza H5N1 by wild birds from Europe to North America in 2021
    Caliendo, V
    Lewis, N. S.
    Pohlmann, A.
    Baillie, S. R.
    Banyard, A. C.
    Beer, M.
    Brown, I. H.
    Fouchier, R. A. M.
    Hansen, R. D. E.
    Lameris, T. K.
    Lang, A. S.
    Laurendeau, S.
    Lung, O.
    Robertson, G.
    van der Jeugd, H.
    Alkie, T. N.
    Thorup, K.
    van Toor, M. L.
    Waldenstrom, J.
    Yason, C.
    Kuiken, T.
    Berhane, Y.
    SCIENTIFIC REPORTS, 2022, 12 (01)
  • [43] Evolution and mutational landscape of highly pathogenic avian influenza strain A(H5N1) in the current outbreak in the USA and global landscape
    Chakraborty, Chiranjib
    Bhattacharya, Manojit
    VIROLOGY, 2024, 600
  • [44] Potential Biological and Climatic Factors That Influence the Incidence and Persistence of Highly Pathogenic H5N1 Avian Influenza Virus in Egypt
    Salaheldin, Ahmed H.
    Kasbohm, Elisa
    El-Naggar, Heba
    Ulrich, Reiner
    Scheibner, David
    Gischke, Marcel
    Hassan, Mohamed K.
    Arafa, Abdel-Satar A.
    Hassan, Wafaa M.
    Abd El-Hamid, Hatem S.
    Hafez, M. Hafez
    Veits, Jutta
    Mettenleiter, Thomas C.
    Abdelwhab, Elsayed M.
    FRONTIERS IN MICROBIOLOGY, 2018, 9
  • [45] Evolution of Highly Pathogenic Avian Influenza H5N1 Virus in Natural Ecosystems of Northern Eurasia (2005-08)
    Lvov, D. K.
    Shchelkanov, M. Yu
    Prilipov, A. G.
    Vlasov, N. A.
    Fedyakina, I. T.
    Deryabin, P. G.
    Alkhovsky, S. V.
    Grebennikova, I. V.
    Zaberezhny, A. D.
    Suarez, D. L.
    AVIAN DISEASES, 2010, 54 (01) : 483 - 495
  • [46] A new clade 2.3.4.4b H5N1 highly pathogenic avian influenza genotype detected in Europe in 2021
    Nagy, Alexander
    Cernikova, Lenka
    Stara, Martina
    ARCHIVES OF VIROLOGY, 2022, 167 (06) : 1455 - 1459
  • [47] Susceptibility of five migratory aquatic birds to H5N1 highly pathogenic avian influenza virus (A/Chicken/Korea/IS/06).
    Kwon, Y. K.
    Swayne, D. E.
    POULTRY SCIENCE, 2008, 87 : 164 - 164
  • [48] Efficacy of a commercial inactivated H5 influenza vaccine against highly pathogenic avian influenza H5N1 in waterfowl evaluated under field conditions
    Rudolf, M.
    Poeppel, M.
    Froehlich, A.
    Mettenleiter, T.
    Beer, M.
    Harder, T.
    REVUE SCIENTIFIQUE ET TECHNIQUE-OFFICE INTERNATIONAL DES EPIZOOTIES, 2009, 28 (01): : 275 - 291
  • [49] Highly pathogenic avian influenza H5N1 virus outbreak among Cape cormorants (Phalacrocorax capensis) in Namibia, 2022
    Molini, Umberto
    Yabe, John
    Meki, Irene K.
    Ben Ali, Hatem Ouled Ahmed
    Settypalli, Tirumala B. K.
    Datta, Sneha
    Coetzee, Lauren Michelle
    Hamunyela, Ellini
    Khaiseb, Siegfried
    Cattoli, Giovanni
    Lamien, Charles E.
    Dundon, William G.
    EMERGING MICROBES & INFECTIONS, 2023, 12 (01)
  • [50] The Impact of Highly Pathogenic Avian Influenza H5N1 in the United States: A Scoping Review of Past Detections and Present Outbreaks
    Mena, Alejandro
    von Fricken, Michael E.
    Anderson, Benjamin D.
    VIRUSES-BASEL, 2025, 17 (03):
12345