Kruppel-like factor 8 emerges as an important regulator of cancer

被引：0
|
作者：
Lahiri, Satadru K. [1 ]
Zhao, Jihe [1 ]
机构：
[1] Univ Cent Florida, Burnett Sch Biomed Sci, Coll Med, Orlando, FL 32827 USA
来源：
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH | 2012年 / 4卷 / 03期
关键词：
Kruppel-like factor 8 (KLF8); cancer; FOCAL ADHESION KINASE; CELL-CYCLE PROGRESSION; KLF8; TRANSCRIPTION; IN-VIVO; IDENTIFICATION; GENE; ACTIVATION; EXPRESSION; INVASION; FINGERS;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Kruppel-like factor 8 (KLF8) is a young member of the KLF transcription factor family proteins. It is highly overexpressed in several types of human cancers and regulates various cellular processes important for tumor progression. Increasing evidence has made KLF8 a new focus in cancer research and a potential target for cancer therapy. This review highlights the role of KLF8 in cancer by summarizing the up-to-date studies into its structure, function as a dual transcription factor, target genes and mechanisms of expression and modifications.
引用
收藏
页码：357 / 363
页数：7
相关论文
共 50 条
  • [21] Kruppel-like Factor 15 (KLF15) Is a Key Regulator of Podocyte Differentiation
    Mallipattu, Sandeep K.
    Liu, Ruijie
    Zheng, Feng
    Narla, Goutham
    Ma'ayan, Avi
    Dikman, Steven
    Jain, Mukesh K.
    Saleem, Moin
    D'Agati, Vivette
    Klotman, Paul
    Chuang, Peter Y.
    He, John C.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (23) : 19122 - 19135
  • [22] Myeloid Kruppel-like factor 2 is a critical regulator of metabolic inflammation
    Sweet, David R.
    Vasudevan, Neelakantan T.
    Fan, Liyan
    Booth, Chloe E.
    Keerthy, Komal S.
    Liao, Xudong
    Vinayachandran, Vinesh
    Takami, Yoichi
    Tugal, Derin
    Sharma, Nikunj
    Chan, E. Ricky
    Zhang, Lilei
    Qing, Yulan
    Gerson, Stanton L.
    Fu, Chen
    Wynshaw-Boris, Anthony
    Sangwung, Panjamaporn
    Nayak, Lalitha
    Holvoet, Paul
    Matoba, Keiichiro
    Lu, Yuan
    Zhou, Guangjin
    Jain, Mukesh K.
    NATURE COMMUNICATIONS, 2020, 11 (01)
  • [23] Kruppel-like factor 5 as potential molecular marker in cervical cancer and the KLF family profile expression
    Marrero-Rodriguez, Daniel
    Taniguchi-Ponciano, Keiko
    Jimenez-Vega, Florinda
    Romero-Morelos, Pablo
    Mendoza-Rodriguez, Monica
    Mantilla, Alejandra
    Rodriguez-Esquivel, Miriam
    Hernandez, Daniel
    Hernandez, Angeles
    Gomez-Gutierrez, Guillermo
    Munoz-Hernandez, Nancy
    Arreola-de la Cruz, Hugo
    Vargas-Requena, Claudia
    Diaz-Hernandez, Cecilia
    Serna-Reyna, Luis
    Meraz-Rios, Marco
    Bandala, Cindy
    Ortiz-Leon, Jorge
    Salcedo, Mauricio
    TUMOR BIOLOGY, 2014, 35 (11) : 11399 - 11407
  • [24] Kruppel-Like Factor 8 Is a New Wnt/Beta-Catenin Signaling Target Gene and Regulator in Hepatocellular Carcinoma
    Yang, Tian
    Cai, Sheng-Yun
    Zhang, Jin
    Lu, Jun-Hua
    Lin, Chuan
    Zhai, Jian
    Wu, Meng-Chao
    Shen, Feng
    PLOS ONE, 2012, 7 (06):
  • [25] Role of kruppel-like factor 8 for therapeutic drug-resistant multi-organ metastasis of breast cancer
    Hao, Jie
    Lu, Heng
    Mukherjee, Debarati
    Yu, Lin
    Zhao, Jihe
    AMERICAN JOURNAL OF CANCER RESEARCH, 2021, 11 (05): : 2188 - 2201
  • [26] Kruppel-like factor 8 involved in hypoxia promotes the invasion and metastasis of gastric cancer via epithelial to mesenchymal transition
    Liu, Na
    Wang, Yafang
    Zhou, Yongan
    Pang, Hailin
    Zhou, Jing
    Qian, Pei
    Liu, Lili
    Zhang, Helong
    ONCOLOGY REPORTS, 2014, 32 (06) : 2397 - 2404
  • [27] The Clinical Relevance and Function of Kruppel-Like Factor 16 in Breast Cancer
    Bang, Soyeon
    Li, Junhong
    Zhang, Meiqin
    Cui, Renjie
    Wu, Xingwen
    Xin, Zhaochen
    Ma, Duan
    Zhang, Jin
    Zhang, Hongwei
    CANCER MANAGEMENT AND RESEARCH, 2020, 12 : 6373 - 6383
  • [28] Association of Kruppel-like factor 2 polymorphisms with the risk of coronary artery disease
    Degirmenci, Ulas
    Yildirim, Metin
    Akkapulu, Merih
    Yalin, Ali Erdinc
    Yilmaz, Dilek Cicek
    Oztornaci, Ragip Onur
    Tasdelen, Bahar
    Yalin, Serap
    CUKUROVA MEDICAL JOURNAL, 2023, 48 (02): : 583 - 592
  • [29] Immunohistochemical localization of Kruppel-like factor 6 in the mouse forebrain
    Jeong, Kyoung Hoon
    Kim, Seul-Ki
    Kim, Seong Yun
    Cho, Kyung-Ok
    NEUROSCIENCE LETTERS, 2009, 453 (01) : 16 - 20
  • [30] Kruppel-like factor 8 activates the transcription of C-X-C cytokine receptor type 4 to promote breast cancer cell invasion, transendothelial migration and metastasis
    Mukherjee, Debarati
    Lu, Heng
    Yu, Lin
    He, Chunjiang
    Lahiri, Satadru K.
    Li, Tianshu
    Zhao, Jihe
    ONCOTARGET, 2016, 7 (17) : 23552 - 23568
12345