Kruppel-like factor 8 emerges as an important regulator of cancer

被引：0

作者：

Lahiri, Satadru K. ^{[1
]}

Zhao, Jihe ^{[1
]}

机构：

[1] Univ Cent Florida, Burnett Sch Biomed Sci, Coll Med, Orlando, FL 32827 USA

来源：

AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH | 2012年 / 4卷 / 03期

关键词：

Kruppel-like factor 8 (KLF8); cancer; FOCAL ADHESION KINASE; CELL-CYCLE PROGRESSION; KLF8; TRANSCRIPTION; IN-VIVO; IDENTIFICATION; GENE; ACTIVATION; EXPRESSION; INVASION; FINGERS;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Kruppel-like factor 8 (KLF8) is a young member of the KLF transcription factor family proteins. It is highly overexpressed in several types of human cancers and regulates various cellular processes important for tumor progression. Increasing evidence has made KLF8 a new focus in cancer research and a potential target for cancer therapy. This review highlights the role of KLF8 in cancer by summarizing the up-to-date studies into its structure, function as a dual transcription factor, target genes and mechanisms of expression and modifications.

引用

页码：357 / 363

页数：7

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