Spin Trapping: An Essential Tool for the Study of Diseases Caused by Oxidative Stress

被引：13

作者：

Barriga-Gonzalez, German ^{[1
]}

Olea-Azar, Claudio ^{[2
]}

Zuniga-Lopez, Maria C. ^{[2
]}

Folch-Cano, Christian ^{[3
]}

Aguilera-Venegas, Benjamin ^{[2
,4
]}

Porcal, Williams ^{[5
]}

Gonzalez, Mercedes ^{[5
]}

Cerecetto, Hugo ^{[5
]}

机构：

[1] Univ Andres Bello, Fac Ciencias Exactas, Dept Ciencias Quim, Santiago 8370146, Chile

[2] Univ Chile, Fac Ciencias Quim & Farmaceut, Dept Quim Inorgan & Analit, Santiago, Chile

[3] Univ Chile, Fac Ciencias Quim & Farmaceut, Dept Quim Organ & Fisicoquim, Santiago, Chile

[4] Univ Chile, Inst Nutr & Tecnol Alimentos, Lab Antioxidantes, Santiago, Chile

[5] Univ Republica, Fac Ciencias, Fac Quim, Grp Quim Med,Lab Quim Organ, Montevideo, Uruguay

来源：

CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2015年 / 15卷 / 05期

关键词：

DMPO; EPR; ESR; Human diseases; Immuno-spin trapping; Oxidative stress; PBN; Spin traps; NITRIC-OXIDE SYNTHASE; ELECTRON-PARAMAGNETIC-RESONANCE; DINITROSYL IRON COMPLEXES; FREE-RADICAL GENERATION; KAPPA-B ACTIVATION; IN-VIVO DETECTION; TRYPANOSOMA-CRUZI; N-OXIDE; ANTIOXIDANT PROPERTIES; LIPID-PEROXIDATION;

D O I：

10.2174/1568026615666150206155108

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Electron spin resonance (ESR), called also electron paramagnetic resonance (EPR) together with the spin trapping technique, has allowed us to study and understand how free radicals are involved in various pathologies. In this review, the importance of spin trapping technique in the study of diseases such as cancer, diabetes, hypertension and parasitic diseases is discussed. In addition, advances in the use of this technique as therapeutic agents and other interesting applications as the immuno-spin trapping technique are reviewed.

引用

页码：484 / 495

页数：12

共 117 条

[1] Identification of the transition state for fast reactions: The trapping of hydroxyl and methyl radicals by DMPO-A DFT approach
Aguilera-Venegas, Benjamin
Speisky, Hernan
[J]. JOURNAL OF MOLECULAR GRAPHICS & MODELLING, 2014, 52 : 57 - 70
[2] Aguilera-Venegas B, 2013, FUTURE MED CHEM, V5, P1843, DOI [10.4155/FMC.13.144, 10.4155/fmc.13.144]
[3] Aguilera-Venegas B, 2012, INT J ELECTROCHEM SC, V7, P5837
[4] ESR, electrochemical, molecular modeling and biological evaluation of 4-substituted and 1,4-disubstituted 7-nitroquinoxalin-2-ones as potential anti-Trypanosoma cruzi agents
Aguilera-Venegas, Benjamin
Olea-Azar, Claudio
Norambuena, Ester
Aran, Vicente J.
Mendizabal, Fernando
Lapier, Michel
Diego Maya, Juan
Kemmerling, Ulrike
Lopez-Munoz, Rodrigo
[J]. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2011, 78 (03) : 1004 - 1012
[5] Metal-dependent generation of reactive oxygen species from amyloid proteins implicated in neurodegenerative disease
Allsop, David
Mayes, Jennifer
Moore, Susan
Masad, Atef
Tabner, Brian J.
[J]. BIOCHEMICAL SOCIETY TRANSACTIONS, 2008, 36 : 1293 - 1298
[6] Synthesis, characterization and anti-Trypanosoma cruzi evaluation of ferrocenyl and cyrhetrenyl imines derived from 5-nitrofurane
Arancibia, Rodrigo
Hugo Klahn, A.
Buono-Core, Gonzalo E.
Gutierrez-Puebla, Enrique
Monge, Angeles
Medina, Manuela E.
Olea-Azar, Claudio
Maya, Juan D.
Godoy, Fernando
[J]. JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2011, 696 (20) : 3238 - 3244
[7] Aravena M, 2010, J CHIL CHEM SOC, V55, P244
[8] Photodynamic anti-cancer effects of fullerene [C60]-PEG complex on fibrosarcomas preferentially over normal fibroblasts in terms of fullerene uptake and cytotoxicity
Asada, Ryoko
Liao, Feng
Saitoh, Yasukazu
Miwa, Nobuhiko
[J]. MOLECULAR AND CELLULAR BIOCHEMISTRY, 2014, 390 (1-2) : 175 - 184
[9] Bardelang D., 2012, ENCY RADICALS CHEM B
[10] New heteroaryl nitrones with spin trap properties: Identification of a 4-furoxanyl derivative with excellent properties to be used in biological systems
Barriga, German
Olea-Azar, Claudio
Norambuena, Ester
Castro, Ana
Porcal, Williams
Gerpe, Alejandra
Gonzalez, Mercedes
Cerecetto, Hugo
[J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2010, 18 (02) : 795 - 802

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