Cytotoxic prenylated flavonoids from Macaranga indica

被引：21

作者：

Yang, Da-Song ^{[1
]}

Peng, Wei-Bing ^{[2
]}

Yang, Yong-Ping ^{[1
]}

Liu, Ke-Chun ^{[2
]}

Li, Xiao-Li ^{[1
]}

Xiao, Wei-Lie ^{[3
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, Inst Tibetan Plateau Res Kunming, Germplasm Bank Wild Species Southwest China,Key L, Kunming 650201, Peoples R China

[2] Shandong Acad Sci, Inst Biol, Jinan 250014, Peoples R China

[3] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China

来源：

FITOTERAPIA | 2015年 / 103卷

基金：

中国国家自然科学基金;

关键词：

Macaranga indica; Euphorbiaceae; Prenylated flavonoids; Ellagic acid; Cytotoxicity; PHENOLIC CONSTITUENTS; AERIAL PARTS; DENTICULATA; LEAVES;

D O I：

10.1016/j.fitote.2015.04.002

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three new prenylated flavonoids, macarindicins A-C (1-3), as well as seven known compounds (4-10) were isolated from the twigs of Macaranga indica. Their structures were elucidated on the basis of extensive spectroscopic interpretation. Compounds 2 and 3 enriched the diversity of prenyl moiety in genus Macaranga especially in the aspect of various lengths of prenyl chain. All the known compounds were isolated from M. indica for the first time and this plant was found to contain large number of ellagic acid. Compounds 1-10 were tested for their cytotoxicity against four cancer cell lines (MCF-7, Hep G2, Hela and P388) and showed IC50 values in the range of 2.61-20.35 mu g/mL. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：187 / 191

页数：5

共 25 条

[1] FARNESYL ACETOPHENONE AND FLAVANONE COMPOUNDS FROM THE AERIAL PARTS OF BORONIA-RAMOSA [J].