L-serine supplementation lowers diabetes incidence and improves blood glucose homeostasis in NOD mice

被引:30
作者
Holm, Laurits J. [1 ]
Haupt-Jorgensen, Martin [1 ]
Larsen, Jesper [1 ]
Giacobini, Jano D. [2 ]
Bilgin, Mesut [2 ]
Buschard, Karsten [1 ]
机构
[1] Rigshosp, Dept Pathol, Bartholin Inst, Copenhagen, Denmark
[2] Danish Canc Soc, Cell Death & Metab Unit, Ctr Autophagy Recycling & Dis, Res Ctr, Copenhagen, Denmark
关键词
INSULIN-SECRETION; BETA-CELLS; TYPE-1; SULFATIDE; SPHINGOLIPIDS; SURVIVAL; LIPIDOME; ROLES;
D O I
10.1371/journal.pone.0194414
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Sphingolipids are a diverse group of lipids with important roles in beta-cell biology regulating insulin folding and controlling apoptosis. Sphingolipid biosynthesis begins with the condensation of L-serine and palmitoyl-CoA. Here we tested the effect of L-serine supplementation on autoimmune diabetes development and blood glucose homeostasis in female NOD mice. We found that continuous supplementation of L-serine reduces diabetes incidence and insulitis score. In addition, L-serine treated mice had an improved glucose tolerance test, reduced HOMA-IR, and reduced blood glucose levels. L-serine led to a small reduction in body weight accompanied by reduced food and water intake. L-serine had no effect on pancreatic sphingolipids as measured by mass spectrometry. The data thus suggests that L-serine could be used as a therapeutic supplement in the treatment of Type 1 Diabetes and to improve blood glucose homeostasis.
引用
收藏
页数:11
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