Preparation of tadpole-shaped calcium alginate microparticles with sphericity control

被引：36

作者：

Dang, T. D. ^{[1
,2
]}

Joo, S. W. ^{[1
]}

机构：

[1] Yeungnam Univ, Sch Mech Engn, Kyongsan 712749, South Korea

[2] Hanoi Univ Sci & Technol, Sch Chem Engn, Hanoi, Vietnam

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2013年 / 102卷

基金：

新加坡国家研究基金会;

关键词：

Microparticles; Sodium alginate; Calcium chloride; Calcium alginate; DELIVERY; EMULSIFICATION; GENERATION; MICROBEADS; PARTICLES; SIZE;

D O I：

10.1016/j.colsurfb.2012.09.016

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Monosized sodium alginate microdroplets are prepared using a flow-focusing microdevice by adjusting the flow rate of the continuous phase (soybean oil) and the dispersed phase (sodium alginate solution). The gelation process of the semi-product, sodium alginate microdroplets, occurs outside the channel in a calcium chloride solution to form tadpole-shaped calcium alginate microparticles. The microparticles prepared are in the range of 100-250 mu m in diameter, depending on the experimental conditions. The shape, size and size distribution of these calcium alginate microparticles depend strongly on the calcium solution concentration and the stirring mode. The shaping mechanism of the microparticles and the impact of the experimental conditions on particle shape and size are investigated. (c) 2012 Elsevier B.V. All rights reserved.

引用

页码：766 / 771

页数：6

共 38 条

[1] Alginate gelation in microfluidic channels [J].

Amici, E. ;

Tetradis-Meris, G. ;

de Torres, Pulido ;

Jousse, F. .

FOOD HYDROCOLLOIDS, 2008, 22 (01) :97-104

[2]

[Anonymous], 2003, CALC CHLOR HDB GUID, P15

[3]

[Anonymous], 1998, SOYB OIL OIL PROP

[4]

Badescu V, 2009, REV ROUM CHIM, V54, P201

[5] Lactose bioconversion by calcium-alginate immobilization of Kluyveromyces lactis cells [J].

Becerra, M ;

Baroli, B ;

Fadda, AM ;

Méndez, JB ;

Siso, MIG .

ENZYME AND MICROBIAL TECHNOLOGY, 2001, 29 (8-9) :506-512

[6] Molecular basis of Ca2+-induced gelation in alginates and pectins:: The egg-box model revisited [J].

Braccini, I ;

Pérez, S .

BIOMACROMOLECULES, 2001, 2 (04) :1089-1096

[7] Microfluidic fabrication of microengineered hydrogels and their application in tissue engineering [J].

Chung, Bong Geun ;

Lee, Kwang-Ho ;

Khademhosseini, Ali ;

Lee, Sang-Hoon .

LAB ON A CHIP, 2012, 12 (01) :45-59

[8] Control of serial microfluidic droplet size gradient by step-wise ramping of flow rates [J].

Collins, John ;

Lee, Abraham Phillip .

MICROFLUIDICS AND NANOFLUIDICS, 2007, 3 (01) :19-25

[9] Capillary threads and viscous droplets in square microchannels [J].

Cubaud, Thomas ;

Mason, Thomas G. .

PHYSICS OF FLUIDS, 2008, 20 (05)

[10] Preparation of monodisperse PEG hydrogel microparticles using a microfluidic flow-focusing device [J].

Dang, Trung-Dung ;

Kim, Young Ho ;

Kim, Hwan Gon ;

Kim, Gyu Man .

JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, 2012, 18 (04) :1308-1313

← 1 2 3 4 →