New, Efficient Approach for the Ligand-Free Suzuki-Miyaura Reaction of 5-Iodo-2′-deoxyuridine in Water

被引：23
作者：
Sartori, Guillaume [1 ]
Herve, Gwenaelle [1 ]
Enderlin, Gerald [1 ]
Len, Christophe [1 ]
机构：
[1] Ctr Rech Royallieu, UTC ESCOM, F-60205 Compiegne, France
来源：
SYNTHESIS-STUTTGART | 2013年 / 45卷 / 03期
关键词：
Suzuki-Miyaura reaction; ligandless; nucleosides; green chemistry; CROSS-COUPLING REACTIONS; NUCLEOSIDE ANALOGS; ELECTRON INJECTION; PALLADIUM; DNA; FLUORESCENT; DERIVATIVES; 2'-DEOXYURIDINE; INHIBITORS; URIDINES;
D O I：
10.1055/s-0032-1317847
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of 5-aryl-2'-deoxyuridines was prepared, using ligandless Suzuki-Miyaura cross-coupling reactions in neat water, starting from 5-iodo-2'-deoxyuridine as totally deprotected starting material. This ligand-free process gave good to high isolated yields within short reaction times and with low loadings of palladium.
引用
收藏
页码：330 / 333
页数：4
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