BK Virus Nephropathy in Kidney Transplantation: An Approach Proposal and Update on Risk Factors, Diagnosis, and Treatment

被引：28

作者：

Gonzalez, S. ^{[1
]}

Escobar-Serna, D. P. ^{[1
]}

Suarez, O. ^{[1
]}

Benavides, X. ^{[1
]}

Escobar-Serna, J. F. ^{[2
]}

Lozano, E. ^{[1
,3
]}

机构：

[1] Univ Nacl Colombia, Sch Med, Dept Surg, Organ & Tissues Transplant Grp, Bogota, Colombia

[2] Univ Antioquia, Internal Med & Crit Care, Medellin, Colombia

[3] Hosp Univ San Ignacio, Bogota, Colombia

来源：

TRANSPLANTATION PROCEEDINGS | 2015年 / 47卷 / 06期

关键词：

POLYOMAVIRUS-ASSOCIATED NEPHROPATHY; RENAL-ALLOGRAFT RECIPIENTS; POLYMERASE-CHAIN-REACTION; ACYCLIC NUCLEOSIDE PHOSPHONATES; LOW-DOSE CIDOFOVIR; LARGE T-ANTIGEN; INTERSTITIAL NEPHRITIS; LOAD MEASUREMENT; IN-VIVO; REPLICATION;

D O I：

10.1016/j.transproceed.2015.05.010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

BK virus belongs to Polyomaviridae family; it causes 95% of nephropathy cases related to polyomavirus, with the other 5% caused by JC virus. Nephropathy jeopardizes graft function, causing a premature failure of the graft in 1%-10% of patients with kidney transplants. Nowadays, antiviral effective treatment is unknown, which is why blood and urine screening of renal transplantation patients has become the most important recommendation to guide the decrease of immunosuppression, and the only proven method to decrease poor outcomes. Different interventions, such as cidofovir, leflunomide, fluoroquinolones, and intravenous immunoglobulin, have been attempted with no improvement at all. This review aims to summarize the most relevant features of BK virus, historical issues, transmission mechanisms, risk factors, and therapeutic interventions.

引用

页码：1777 / 1785

页数：9

共 122 条

[91] Prevalence and patterns of polyomavirus urinary excretion in immunocompetent adults and children [J].

Polo, C ;

Pérez, JL ;

Mielnichuck, A ;

Fedele, CG ;

Niubò, J ;

Tenorio, A .

CLINICAL MICROBIOLOGY AND INFECTION, 2004, 10 (07) :640-644

[92] SUPPRESSION OF BK VIRUS-REPLICATION AND CYTOPATHIC EFFECT BY INHIBITORS OF PROKARYOTIC DNA GYRASE [J].

PORTOLANI, M ;

PIETROSEMOLI, P ;

CERMELLI, C ;

MANNINIPALENZONA, A ;

GROSSI, MP ;

PAOLINI, L ;

BARBANTIBRODANO, G .

ANTIVIRAL RESEARCH, 1988, 9 (03) :205-218

[93] Risk factors for polyoma virus nephropathy [J].

Prince, Olivier ;

Savic, Spasenija ;

Dickenmann, Michael ;

Steiger, Jurg ;

Bubendorf, Lukas ;

Mihatsch, Michael J. .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2009, 24 (03) :1024-1033

[94] Efficacy of CMX001 against Herpes Simplex Virus Infections in Mice and Correlations with Drug Distribution Studies [J].

Quenelle, Debra C. ;

Lampert, Bernhardt ;

Collins, Deborah J. ;

Rice, Terri L. ;

Painter, George R. ;

Kern, Earl R. .

JOURNAL OF INFECTIOUS DISEASES, 2010, 202 (10) :1492-1499

[95] Clinical course of polyoma virus nephropathy in 67 renal transplant patients [J].

Ramos, E ;

Drachenberg, CB ;

Papadimitriou, JC ;

Hamze, O ;

Fink, JC ;

Klassen, DK ;

Drachenberg, RC ;

Wiland, A ;

Wali, R ;

Cangro, CB ;

Schweitzer, E ;

Bartlet, ST ;

Weir, MR .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2002, 13 (08) :2145-2151

[96] Ether lipid ester derivatives of cidofovir inhibit polyomavirus BK replication in vitro [J].

Randhawa, P ;

Farasati, NA ;

Shapiro, R ;

Hostetler, KY .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2006, 50 (04) :1564-1566

[97] Monitoring for polyomavirus BK and JC in urine: Comparison of quantitative polymerase chain reaction with urine cytology [J].

Randhawa, P ;

Vats, A ;

Shapiro, R .

TRANSPLANTATION, 2005, 79 (08) :984-986

[98] Identification of species-specific and cross-reactive epitopes in human polyomavirus capsids using monoclonal antibodies [J].

Randhawa, Parmjeet ;

Viscidi, Raphael ;

Carter, Joseph J. ;

Galloway, Denise A. ;

Culp, Tim D. ;

Huang, Cathy ;

Ramaswami, Bala ;

Christensen, Neil D. .

JOURNAL OF GENERAL VIROLOGY, 2009, 90 :634-639

[99] Anesthesia and Kidney Transplantation [J].

Ricaurte, L. ;

Vargas, J. ;

Lozano, E. ;

Diaz, L. .

TRANSPLANTATION PROCEEDINGS, 2013, 45 (04) :1386-1391

[100] Antivirals for the treatment of polyomavirus BK replication [J].

Rinaldo, Christine Hanssen ;

Hirsch, Hans H. .

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY, 2007, 5 (01) :105-115

← 4 5 6 7 8 9 10 11 12 13 →