Exacerbated CSF abnormalities in younger patients with Alzheimer's disease

被引：15

作者：

Dumurgier, Julien ^{[1
]}

Gabelle, Audrey ^{[2
,3
]}

Vercruysse, Olivier ^{[4
,5
]}

Bombois, Stephanie ^{[4
]}

Laplanche, Jean-Louis ^{[6
]}

Peoc'h, Katell ^{[6
]}

Schraen, Susanna ^{[5
,7
]}

Sablonniere, Bernard ^{[5
,7
]}

Pasquier, Florence ^{[4
]}

Touchon, Jacques ^{[2
]}

Lehmann, Sylvain ^{[3
]}

Hugon, Jacques ^{[1
,8
]}

Paquet, Claire ^{[1
,8
]}

机构：

[1] Univ Paris 07, Fernand Widal Hosp, AP HP, Ctr Memoire Ressources Rech Paris Nord Ile de Fra, Paris, France

[2] Univ Montpellier, Ctr Memoire Ressources Rech Montpellier, F-34059 Montpellier, France

[3] Univ Montpellier, INSERM, CCBHM, IRB,U1040, F-34059 Montpellier, France

[4] Lille Univ Hosp, Ctr Memoire Ressources Rech Lille, EA 1046, Lille, France

[5] Univ Lille Nord France, INSERM, Jean Pierre Aubert Res Ctr, U837, Lille, France

[6] Hop Fernand Widal, AP HP, PRES Sorbonne, Serv Biochim & Biol Mol, F-75010 Paris, France

[7] Lille Univ Hosp, Ctr Biol Pathol UF Neurobiol, Lille, France

[8] INSERM, Inst Fer Moulin, U839, Paris, France

来源：

NEUROBIOLOGY OF DISEASE | 2013年 / 54卷

关键词：

Alzheimer's disease; CSF biomarkers; Age factor; Epidemiology; CEREBROSPINAL-FLUID; DEMENTIA; ONSET; AGE; BIOMARKERS; PREVALENCE; DIAGNOSIS; BETA; NEUROPATHOLOGY; ACCUMULATION;

D O I：

10.1016/j.nbd.2013.01.023

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Increasing age is the most important risk factor for developing Alzheimer's disease (AD). The aim of this study was to investigate the relationships between age and cerebrospinal fluid (CSF) levels of beta-amyloid (A beta 1-42), total Tau and phosphorylated Tau (pTau-181), in AD and non-AD patients explored for cognitive disorders. 966 patients (AD, n = 528; non-AD, n = 438) were included between January 2008 and December 2010 (mean age, 69.5 years; mean MMSE, 20.2) from three French memory centers. Multivariable linear regression models were used to study the relationship between CSF biomarker levels and age in AD and non-AD patients. The capacity of each CSF biomarker in discriminating patients was evaluated using the area under the receiver-operating characteristic (ROC) curves by quartile of distribution of age. In AD patients, older age was associated with higher CSF A beta 1-42 and lower Tau levels. Conversely, in non-AD patients, age was associated with lower CSF A beta 1-42, higher Tau, and higher pTau-181 levels. In sex-stratified analysis, these relationships were significant only in women. Using ROC curve analysis, CSF AD biomarkers were more discriminant in younger patients than in older ones. In this clinically-based study, younger patients with AD had exacerbated CSF anomalies compared to older patients with AD. CSF biomarkers were more discriminant in younger patients than in older ones for the diagnosis of AD, especially in women. These results support the idea of an overlap in AD neuropathological lesions in oldest subjects with or without AD. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：486 / 491

页数：6

共 42 条

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