Targeting heat shock proteins in cancer

被引：344

作者：

Jego, Gaetan ^{[1
,2
]}

Hazoume, Adonis ^{[1
]}

Seigneuric, Renaud ^{[1
,2
,3
]}

Garrido, Carmen ^{[1
]}

机构：

[1] INSERM, U866, F-21033 Dijon, France

[2] Univ Burgundy, F-21078 Dijon, France

[3] CNRS, UMR 5209, ICB, Dept Nanosci, F-21078 Dijon, France

来源：

CANCER LETTERS | 2013年 / 332卷 / 02期

关键词：

Heat shock proteins; Apoptosis; Immunogenicity; Cancer cell growth; Cancer cell resistance; BREAST-CANCER; CHAPERONE FUNCTION; HSP90; INHIBITOR; IN-VITRO; BCR-ABL; CONFERS RESISTANCE; ANTITUMOR-ACTIVITY; ANDROGEN ABLATION; CRYSTAL-STRUCTURE; ATPASE ACTIVITY;

D O I：

10.1016/j.canlet.2010.10.014

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Heat shock proteins (HSPs) HSP27, HSP70 and HSP90 are powerful chaperones. Their expression is induced in response to a wide variety of physiological and environmental insults including anti-cancer chemotherapy, thus allowing the cell to survive to lethal conditions. Different functions of HSPs have been described to account for their cytoprotective function, including their role as molecular chaperones as they play a central role in the correct folding of misfolded proteins, but also their anti-apoptotic properties. HSPs are often overexpressed in cancer cells and this constitutive expression is necessary for cancer cells' survival. HSPs may have oncogene-like functions and likewise mediate "non-oncogene addiction" of stressed tumor cells that must adapt to a hostile microenvironment, thereby becoming dependent for their survival on HSPs. HSP-targeting drugs have therefore emerged as potential anti-cancer agents. This review describes the different molecules and approaches being used or proposed in cancer therapy based on the in inhibition of HSP90, HSP70 and HSP27. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

引用

页码：275 / 285

页数：11

共 102 条

[11] Heat shock proteins in cancer: chaperones of tumorigenesis [J].

Calderwood, SK ;

Khaleque, MA ;

Sawyer, DB ;

Ciocca, DR .

TRENDS IN BIOCHEMICAL SCIENCES, 2006, 31 (03) :164-172

[12] A purine scaffold Hsp90 inhibitor destabilizes BCL-6 and has specific antitumor activity in BCL-6-dependent B cell lymphomas [J].

Cerchietti, Leandro C. ;

Lopes, Eloisi C. ;

Yang, Shao Ning ;

Hatzi, Katerina ;

Bunting, Karen L. ;

Tsikitas, Lucas A. ;

Mallik, Alka ;

Robles, Ana I. ;

Walling, Jennifer ;

Varticovski, Lyuba ;

Shaknovich, Rita ;

Bhalla, Kapil N. ;

Chiosis, Gabriela ;

Melnick, Ari .

NATURE MEDICINE, 2009, 15 (12) :1369-U3

[13] GCUNC45 is the first Hsp90 co-chaperone to show α/β isoform specificity [J].

Chadli, Ahmed ;

Felts, Sara J. ;

Toft, David O. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (15) :9509-9512

[14] Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells [J].

Chalmin, Fanny ;

Ladoire, Sylvain ;

Mignot, Gregoire ;

Vincent, Julie ;

Bruchard, Melanie ;

Remy-Martin, Jean-Paul ;

Boireau, Wilfrid ;

Rouleau, Alain ;

Simon, Benoit ;

Lanneau, David ;

De Thonel, Aurelie ;

Multhoff, Gabriele ;

Hamman, Arlette ;

Martin, Francois ;

Chauffert, Bruno ;

Solary, Eric ;

Zitvogel, Laurence ;

Garrido, Carmen ;

Ryffel, Bernhard ;

Borg, Christophe ;

Apetoh, Lionel ;

Rebe, Cedric ;

Ghiringhelli, Francois .

JOURNAL OF CLINICAL INVESTIGATION, 2010, 120 (02) :457-471

[15] Inhibitors of HSP90 block p95-HER2 signaling in Trastuzumab-resistant tumors and suppress their growth [J].

Chandarlapaty, S. ;

Scaltriti, M. ;

Angelini, P. ;

Ye, Q. ;

Guzman, M. ;

Hudis, C. A. ;

Norton, L. ;

Solit, D. B. ;

Arribas, J. ;

Baselga, J. ;

Rosen, N. .

ONCOGENE, 2010, 29 (03) :325-334

[16] Involvement of calcium in the differential induction of heat shock protein 70 by heat shock protein 90 inhibitors, geldanamycin and radicicol, in human non-small cell lung cancer H460 cells [J].

Chang, YS ;

Lee, LC ;

Sun, FC ;

Chao, CC ;

Fu, HW ;

Lai, YK .

JOURNAL OF CELLULAR BIOCHEMISTRY, 2006, 97 (01) :156-165

[17]

Chauhan D, 2003, CANCER RES, V63, P6174

[18] Chemical ablation of androgen receptor in prostate cancer cells by the histone deacetylase inhibitor LAQ824 [J].

Chen, LW ;

Meng, SS ;

Wang, H ;

Bali, P ;

Bai, WL ;

Li, BY ;

Atadja, P ;

Bhalla, KN ;

Wu, J .

MOLECULAR CANCER THERAPEUTICS, 2005, 4 (09) :1311-1319

[19] The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors [J].

Cheung, KMJ ;

Matthews, TP ;

James, K ;

Rowlands, MG ;

Boxall, KJ ;

Sharp, SY ;

Maloney, A ;

Roe, SM ;

Prodromou, C ;

Pearl, LH ;

Aherne, GW ;

McDonald, E ;

Workman, P .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (14) :3338-3343

[20] A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells [J].

Chiosis, G ;

Timaul, MN ;

Lucas, B ;

Munster, PN ;

Zheng, FF ;

Sepp-Lorenzino, L ;

Rosen, N .

CHEMISTRY & BIOLOGY, 2001, 8 (03) :289-299

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