Clinicopathologic characteristics and prognosis of young patients with breast cancer

被引：27

作者：

Han, Ji-guang ^{[1
]}

Jiang, Yong-dong ^{[1
]}

Zhang, Chun-hui ^{[2
]}

Pang, Da ^{[1
]}

Zhang, Ming ^{[3
]}

Wang, Yan-bo ^{[1
]}

Xue, Wei-nan ^{[1
]}

Sun, Qian ^{[1
]}

机构：

[1] Harbin Med Univ, Affiliated Tumor Hosp, Dept Breast Surg, Harbin 150040, Peoples R China

[2] Harbin Med Univ, Affiliated Tumor Hosp, Dept Oncol, Harbin 150040, Peoples R China

[3] Harbin Med Univ, Affiliated Tumor Hosp, Dept Surg Gastroenterol, Harbin 150040, Peoples R China

来源：

BREAST | 2011年 / 20卷 / 04期

关键词：

Age; Breast cancer; Prognosis; Survival; POORER PROGNOSIS; AGE; SURVIVAL; WOMEN; DIAGNOSIS; STAGE; CARCINOMA; CHEMOTHERAPY; PREGNANCY; FEATURES;

D O I：

10.1016/j.breast.2011.02.011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: The aim was to describe the clinicopathological features and prognosis of young patients with breast cancer. Patients and Methods: We reviewed the records of 1478 consecutive patients aged <= 50 years with first diagnosis of invasive breast cancer referred to surgery from January 1999 to March 2005. A total of 174 patients were aged <35 years (group I) and 1304 were aged 35-50 years (group II). Results: Compared with patients of group II, patients of group I had a higher percentage of tumors classified as estrogen receptors (ER) negative, progesterone receptors (PR) negative, with a Ki-67 labeling index >= 20% of the cells. The 5-year survival of group I was 78.3% as compared with 84.2% for group II (P = 0.006). Conclusion: Compared with patients aged between 35 and 50 years, patients aged <35 years have a greater chance of having an endocrine-unresponsive tumor and a significantly poor prognosis. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：370 / 372

页数：3

共 28 条

[1] THE RELATION BETWEEN SURVIVAL AND AGE AT DIAGNOSIS IN BREAST-CANCER [J].

ADAMI, HO ;

MALKER, B ;

HOLMBERG, L ;

PERSSON, I ;

STONE, B .

NEW ENGLAND JOURNAL OF MEDICINE, 1986, 315 (09) :559-563

[2] Is chemotherapy alone adequate for young women with oestrogen-receptor-positive breast cancer? [J].

Aebi, S ;

Gelber, S ;

Castiglione-Gertsch, M ;

Gelber, RD ;

Collins, J ;

Thürlimann, B ;

Rudenstam, CM ;

Lindtner, J ;

Crivellari, D ;

Cortes-Funes, H ;

Simoncini, E ;

Werner, ID ;

Coates, AS ;

Goldhirsch, A .

LANCET, 2000, 355 (9218) :1869-1874

[3] Breast cancers among very young premenopausal women (United States) [J].

Althuis, MD ;

Brogan, DD ;

Coates, RJ ;

Daling, JR ;

Gammon, MD ;

Malone, KE ;

Schoenberg, JB ;

Brinton, LA .

CANCER CAUSES & CONTROL, 2003, 14 (02) :151-160

[4]

American Joint Committee on Cancer, 1997, AJCC CANC STAG MAN, P171

[5]

[Anonymous], 2000, SURV EP END RES SEER

[6] Age at diagnosis, extent of disease and breast cancer survival: A population-based study in Florence, Italy [J].

Barchielli, A ;

Balzi, D .

TUMORI JOURNAL, 2000, 86 (02) :119-123

[7] Do younger female breast cancer patients have a poorer prognosis? Results from a population-based survival analysis [J].

Chia, KS ;

Du, WB ;

Sankaranarayanan, R ;

Sankila, R ;

Wang, H ;

Lee, J ;

Seow, A ;

Lee, HP .

INTERNATIONAL JOURNAL OF CANCER, 2004, 108 (05) :761-765

[8]

Chung M, 1996, CANCER, V77, P97, DOI 10.1002/(SICI)1097-0142(19960101)77:1<97::AID-CNCR16>3.3.CO

[9]

2-T

[10] Very young women (<35 years) with operable breast cancer:: features of disease at presentation [J].

Colleoni, M ;

Rotmensz, N ;

Robertson, C ;

Orlando, L ;

Viale, G ;

Renne, G ;

Luini, A ;

Veronesi, P ;

Intra, M ;

Orecchia, R ;

Catalano, G ;

Galimberti, V ;

Nolé, F ;

Martinelli, G ;

Goldhirsch, A .

ANNALS OF ONCOLOGY, 2002, 13 (02) :273-279

← 1 2 3 →