Mitophagy: A process that adapts to the cell physiology

被引：19

作者：

Bhatia-Kissova, Ingrid ^{[1
]}

Camougrand, Nadine ^{[2
]}

机构：

[1] Comenius Univ, Dept Biochem, Fac Nat Sci, Bratislava 84215, Slovakia

[2] Univ Bordeaux 2, CNRS, UMR5095, F-33077 Bordeaux, France

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2013年 / 45卷 / 01期

关键词：

Mitophagy; Yeast; Mitochondria quality control; MITOCHONDRIAL AUTOPHAGY; DEGRADATION; PROTEIN; ATG32; NIX;

D O I：

10.1016/j.biocel.2012.07.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This focus makes a case that mitophagy is not a straightforward process obeying simple rules. It is a complex process through which the cell gets rid of both damaged and healthy untainted mitochondria to adjust their amount, and in accordance with cellular energy requirements. Several aspects of mitophagy have been described in both yeast and mammalian cells. They have revealed a number of discrepancies in the regulation of this process in the two eukaryotic models. Data have shown that mitophagy is a function of cell physiology. This article is part of a Directed Issue entitled: Bioenergetic dysfunction, adaptation and therapy. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：30 / 33

页数：4

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