Assembly of a cohort of children treated for acute myeloid leukemia at free-standing children's hospitals in the United States using an administrative database

被引：31

作者：

Kavcic, Marko ^{[1
]}

Fisher, Brian T. ^{[2
,3
,4
]}

Torp, Kari ^{[1
]}

Li Yimei ^{[1
]}

Huang, Yuan-Shung ^{[4
]}

Seif, Alix E. ^{[1
,4
]}

Vujkovic, Marijana ^{[1
]}

Aplenc, Richard ^{[1
,3
,4
,5
]}

机构：

[1] Childrens Hosp Philadelphia, Div Oncol, Philadelphia, PA 19104 USA

[2] Childrens Hosp Philadelphia, Div Infect Dis, Philadelphia, PA 19104 USA

[3] Childrens Hosp Philadelphia, Ctr Pediat Clin Effectiveness, Philadelphia, PA 19104 USA

[4] Univ Penn, Sch Med, Dept Pediat, Philadelphia, PA 19104 USA

[5] Univ Penn, Sch Med, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA

来源：

PEDIATRIC BLOOD & CANCER | 2013年 / 60卷 / 03期

关键词：

cohort validation; health administrative data; pediatric acute myeloid leukemia; TREATMENT-RELATED MORTALITY; TRIAL; CHEMOTHERAPY; THERAPY;

D O I：

10.1002/pbc.24402

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pediatric Health Information System data were used to establish a multi-center cohort of 1,686 children treated for newly diagnosed acute myeloid leukemia (AML). The cohort assembly process, which included myeloid leukemia ICD-9 discharge diagnosis codes and manual review of induction chemotherapy, was validated by chart review at a single institution. The use of ICD-9 codes alone resulted in a poor positive predictive value (PPV; 31%). Inclusion of the results from the chemotherapy review improved the PPV to 100% without compromising sensitivity (95.7%). This cohort provides a reliable source for future comparative effectiveness and clinical epidemiology studies in pediatric AML. Pediatr Blood Cancer 2013; 60: 508-511. (C) 2012 Wiley Periodicals, Inc.

引用

页码：508 / 511

页数：4

共 14 条

[1] Development and use of reporting guidelines for assessing the quality of validation studies of health administrative data [J].

Benchimol, Eric I. ;

Manuel, Douglas G. ;

To, Teresa ;

Griffiths, Anne M. ;

Rabeneck, Linda ;

Guttmann, Astrid .

JOURNAL OF CLINICAL EPIDEMIOLOGY, 2011, 64 (08) :821-829

[2] AAML03P1, a pilot study of the safety of gemtuzumab ozogamicin in combination with chemotherapy for newly diagnosed childhood acute myeloid leukemia [J].

Cooper, Todd M. ;

Franklin, Janet ;

Gerbing, Robert B. ;

Alonzo, Todd A. ;

Hurwitz, Craig ;

Raimondi, Susana C. ;

Hirsch, Betsy ;

Smith, Franklin O. ;

Mathew, Prasad ;

Arceci, Robert J. ;

Feusner, James ;

Iannone, Robert ;

Lavey, Robert S. ;

Meshinchi, Soheil ;

Gamis, Alan .

CANCER, 2012, 118 (03) :761-769

[3] Early deaths and treatment-related mortality in children undergoing therapy for acute myeloid leukemia: Analysis of the multicenter clinical trials AML-BFM 93 and AML-BFM 98 [J].

Creutzig, U ;

Zimmermann, M ;

Reinhardt, D ;

Dworzak, M ;

Stary, J ;

Lehrnbecher, T .

JOURNAL OF CLINICAL ONCOLOGY, 2004, 22 (21) :4384-4393

[4] Lack of clarity in the definition of treatment-related mortality: pediatric acute leukemia and adult acute promyelocytic leukemia as examples [J].

Ethier, Marie-Chantal ;

Blanco, Esther ;

Lehrnbecher, Thomas ;

Sung, Lillian .

BLOOD, 2011, 118 (19) :5080-5083

[5] Risk Factors for Renal Failure in Pediatric Patients With Acute Myeloid Leukemia: A Retrospective Cohort Study [J].

Fisher, Brian T. ;

Zaoutis, Theoklis E. ;

Leckerman, Kateri H. ;

Localio, Russell ;

Aplenc, Richard .

PEDIATRIC BLOOD & CANCER, 2010, 55 (04) :655-661

[6]

Fisher BT, 2012, MED CARE

[7] Results of a randomized trial in children with Acute Myeloid Leukaemia: Medical Research Council AML12 trial [J].

Gibson, Brenda E. S. ;

Webb, David K. H. ;

Howman, Andrew J. ;

De Graaf, Siebold S. N. ;

Harrison, Christine J. ;

Wheatley, Keith .

BRITISH JOURNAL OF HAEMATOLOGY, 2011, 155 (03) :366-376

[8] Randomized comparison of DAT versus ADE as induction chemotherapy in children and younger adults with acute myeloid leukemia. Results of the Medical Research Council's 10th AML trial (MRC AML10) [J].

Hann, IM ;

Stevens, RF ;

Goldstone, AH ;

Rees, JKH ;

Wheatley, K ;

Gray, RG ;

Burnett, AK .

BLOOD, 1997, 89 (07) :2311-2318

[9] Acute myeloid leukemia in the real world: why population-based registries are needed [J].

Juliusson, Gunnar ;

Lazarevic, Vladimir ;

Horstedt, Ann-Sofi ;

Hagberg, Oskar ;

Hoglund, Martin .

BLOOD, 2012, 119 (17) :3890-3899

[10] Pediatric acute myeloid leukemia: international progress and future directions [J].

Kaspers, GJL ;

Creutzig, U .

LEUKEMIA, 2005, 19 (12) :2025-2029

← 1 2 →