Synthesis of 1,2,4-triazines and the triazinoisoquinolinedione DEF ring system of noelaquinone

被引：6

作者：

Cao, Liming

Maciejewski, John P.

Elzner, Stephan

Amantini, David

Wipf, Peter ^{[1
]}

机构：

[1] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2012年 / 10卷 / 30期

基金：

美国国家卫生研究院;

关键词：

AZA-WITTIG REACTION; VIRIDIN; FURANOSTEROIDS; XESTOSPONGIA; DERIVATIVES; WORTMANNIN; THIAZOLINE; INHIBITOR;

D O I：

10.1039/c2ob25353d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The intramolecular Staudinger-aza-Wittig reaction is used for a general synthesis of 1,2,5,6-tetrahydro-1,2,4-triazines, a structural motif reported for the natural product noelaquinone. The DEF moiety of noelaquinone was obtained in 13 steps and 2% overall yield, and the structure of the synthetic product was confirmed by X-ray analysis.

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收藏

页码：5811 / 5814

页数：4

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