Efficient inhibition of muscle and liver glycogen phosphorylases by a new glucopyranosylidene-spiro-thiohydantoin

被引：91

作者：

Ösz, E

Somsák, L

Szilágyi, L

Kovács, L

Docsa, T

Tóth, B

Gergely, P

机构：

[1] Lajos Kossuth Univ, Dept Organ Chem, H-4010 Debrecen, Hungary

[2] Debrecen Univ Med, Dept Med Chem, H-4026 Debrecen, Hungary

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 10期

关键词：

D O I：

10.1016/S0960-894X(99)00192-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Reaction of C-(1-bromo-1-deoxy-beta-D-glucopyranosyl)forma 2 with thiocyanate ions was the key step of a short synthesis of D-glucopyranosylidene-spiro-thiohydantoin 7 which proved to be a potent inhibitor of muscle and liver glycogen phosphorylases. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：1385 / 1390

页数：6

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