Kallikrein-related peptidase 10 expression in salivary gland tissues and tumours

被引：3

作者：

Darling, Mark R. ^{[1
]}

Hashem, Nelly N. ^{[1
]}

Zhang, Irene ^{[2
]}

Mohamed, Mohamed ^{[2
]}

Fung, Kevin ^{[2
]}

Kwan, Keith ^{[1
]}

Mara, Tom W. ^{[3
]}

Daley, Tom D. ^{[1
]}

Diamandis, Eleftherios P. ^{[4
,5
]}

机构：

[1] Univ Western Ontario, Schulich Sch Med & Dent, Dept Pathol, London, ON N6A 5C1, Canada

[2] Univ Western Ontario, Schulich Sch Med & Dent, Dept Otolaryngol, Div Head & Neck Oncol & Reconstruct Surg, London, ON N6A 5C1, Canada

[3] Univ Western Ontario, Schulich Sch Med & Dent, Dept Oral Med & Radiol, London, ON N6A 5C1, Canada

[4] Univ Toronto, Mt Sinai Hosp, Dept Pathol & Lab Med, Toronto, ON M5S 1A1, Canada

[5] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON M5S 1A1, Canada

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS | 2012年 / 27卷 / 04期

关键词：

Immunoexpression profile; Kallikrein-related peptidases; Salivary gland tumours; PROSTATE-SPECIFIC ANTIGEN; BREAST-CANCER; IMMUNOHISTOCHEMICAL LOCALIZATION; BIOLOGICAL-FLUIDS; SERINE-PROTEASE; DOWN-REGULATION; GENE; FAMILY; IDENTIFICATION; ASSOCIATION;

D O I：

10.5301/JBM.2012.10373

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Objectives: Kallikrein-related peptidase 10 (KLK10) has been implicated in the development of several types of cancer. The purpose of this study was to analyze the expression of KLK10 in 3 types of salivary gland tumour and normal salivary glands. Materials and methods: A standard immunoperoxidase staining technique was used to assess the immunoexpression profile of KLK10 in normal salivary glands and 3 types of salivary gland tumour: pleomorphic adenoma, adenoid cystic carcinoma and mucoepidermoid carcinoma. Results: Pleomorphic adenomas showed significantly lower KLK10 levels than control tissues. Neither of the malignant tumours (adenoid cystic carcinoma and mucoepidermoid carcinoma) showed a significant alteration in the immunoreactive scores of KLK10 in comparison with the normal salivary gland tissues. KLK10 immunoreactive scores were comparable in adenoid cystic carcinoma and mucoepidermoid carcinoma. Pleomorphic adenoma had significantly lower levels of KLK10 than mucoepidermoid carcinoma. Conclusions: The finding of lower KLK10 levels in pleomorphic adenoma suggests aberrant expression in a tumour that develops primarily from myoepithelial cells. A kallikrein cascade may play a role in the development and/or outcome of some salivary gland tumours.

引用

页码：E381 / E388

页数：8

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