RETINAL VASCULAR DEVELOPMENT WITH 0.312 MG INTRAVITREAL BEVACIZUMAB TO TREAT SEVERE POSTERIOR RETINOPATHY OF PREMATURITY A Longitudinal Fluorescein Angiographic Study

被引:60
作者
Lorenz, Birgit [1 ]
Stieger, Knut [1 ]
Jaeger, Melanie [1 ]
Mais, Christine [1 ]
Stieger, Susann [1 ]
Andrassi-Darida, Monika [1 ]
机构
[1] Justus Liebig Univ Giessen, Dept Ophthalmol, Friedrichstr 18, D-35385 Giessen, Germany
来源
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES | 2017年 / 37卷 / 01期
关键词
acute retinopathy of prematurity; aggressive posterior retinopathy of prematurity; fluorescein angiography; bevacizumab; vascular development; ENDOTHELIAL GROWTH-FACTOR; ZONE-I; INJECTION; PHARMACOKINETICS; PRETHRESHOLD; MONOTHERAPY; THERAPY; INFANTS; AVASTIN; DOSAGE;
D O I
10.1097/IAE.0000000000001126
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Purpose: To report the outcome of intravitreal 0.312 mg bevacizumab (IVB) monotherapy in acute retinopathy of prematurity (ROP) and to describe the vascular development over time. Methods: Seventeen prematurely born infants were treated with IVB (0.312 mg in 0.025 mL per eye) because of acute ROP in posterior Zone II or Zone I, including aggressive posterior ROP. Infants were examined by fluorescein angiography (FA) using RetCam II or III (Clarity Medical Systems Inc) before IVB (n = 21 eyes), within 6 weeks (n = 23 eyes), 8 to 13 weeks (n = 22 eyes), and up to 45 months (n = 10 eyes). Results: Acute ROP regressed in 19 out of 27 analyzed eyes (70%), including 100% and 80% of posterior Zone II and Zone I eyes, respectively, but only 25% of aggressive posterior ROP eyes. Early recurrences (11%, all aggressive posterior ROP) and late reactivations (18%) were observed within 1 week and at 9 to 12 weeks, respectively. All eyes showed leakage at the junction of the vascularized zone and capillary malformation on FA before treatment. Vessel branching abnormalities and circumferential vessel formation were typical FA features after treatment. Vascular outgrowth after one IVB became complete in 87.5% of eyes for which FA was available up to at least 9 weeks after IVB. Conclusion: A single dose of 0.312 mg bevacizumab was efficient to induce regression of ROP in posterior Zone II and most of Zone I cases, but not in aggressive posterior ROP. FA describes vascular abnormalities, the importance of which warrants further investigation.
引用
收藏
页码:97 / 111
页数:15
相关论文
共 37 条
[1]   Fluorescein angiography to estimate normal peripheral retinal nonperfusion in children [J].
Blair, Michael P. ;
Shapiro, Michael J. ;
Hartnett, M. Elizabeth .
JOURNAL OF AAPOS, 2012, 16 (03) :234-237
[2]   Unusual Adverse Choroidal Reaction to Intravitreal Bevacizumab in Aggressive Posterior Retinopathy of Prematurity: The Indian Twin Cities ROP Screening (ITCROPS) Data Base Report Number 7 [J].
Chhablani, Jay ;
Rani, Padmaja Kumari ;
Balakrishnan, Divya ;
Jalali, Subhadra .
SEMINARS IN OPHTHALMOLOGY, 2014, 29 (04) :222-225
[3]   Combination of laser photocoagulation and intravitreal bevacizumab (Avastin®) for aggressive zone I retinopathy of prematurity [J].
Chung, Eun Jee ;
Kim, Ji Hyun ;
Ahn, Hyun Seok ;
Koh, Hyoung Jun .
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 2007, 245 (11) :1727-1730
[4]   Increased dietary intake of ω-3-polyunsaturated fatty acids reduces pathological retinal angiogenesis [J].
Connor, Kip M. ;
SanGiovanni, John Paul ;
Lofqvist, Chatarina ;
Aderman, Christopher M. ;
Chen, Jing ;
Higuchi, Akiko ;
Hong, Song ;
Pravda, Elke A. ;
Majchrzak, Sharon ;
Carper, Deborah ;
Hellstrom, Ann ;
Kang, Jing X. ;
Chew, Emily Y. ;
Salem, Norman, Jr. ;
Serhan, Charles N. ;
Smith, Lois E. H. .
NATURE MEDICINE, 2007, 13 (07) :868-873
[5]   Intravitreal bevacizumab for retinopathy of prematurity as first line or rescue therapy with focal laser treatment. A case series [J].
Dani, Carlo ;
Frosini, Saverio ;
Fortunato, Pina ;
Bertini, Giovanna ;
Pratesi, Simone ;
Pollazzi, Liliana ;
Caputo, Roberto ;
La Torre, Agostino .
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, 2012, 25 (11) :2194-2197
[6]   Development of the retinal vasculature [J].
Fruttiger M. .
Angiogenesis, 2007, 10 (2) :77-88
[7]  
GARNER A, 1984, ARCH OPHTHALMOL-CHIC, V102, P1130
[8]   VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia [J].
Gerhardt, H ;
Golding, M ;
Fruttiger, M ;
Ruhrberg, C ;
Lundkvist, A ;
Abramsson, A ;
Jeltsch, M ;
Mitchell, C ;
Alitalo, K ;
Shima, D ;
Betsholtz, C .
JOURNAL OF CELL BIOLOGY, 2003, 161 (06) :1163-1177
[9]   The international classification of retinopathy of prematurity revisited [J].
Gole, GA ;
Ells, AL ;
Katz, X ;
Holmstrom, G ;
Fielder, AR ;
Capone, A ;
Flynn, JT ;
Good, WG ;
Holmes, JM ;
McNamara, JA ;
Palmer, EA ;
Quinn, GE ;
Shapiro, MJ ;
Trese, MGJ ;
Wallace, DK .
ARCHIVES OF OPHTHALMOLOGY, 2005, 123 (07) :991-999
[10]  
Good WV, 2003, ARCH OPHTHALMOL-CHIC, V121, P1684