Emerging views of the nucleus as a cellular mechanosensor

被引：386

作者：

Kirby, Tyler J. ^{[1
,2
]}

Lammerding, Jan ^{[1
,2
]}

机构：

[1] Cornell Univ, Nancy E & Peter C Meinig Sch Biomed Engn, Ithaca, NY 14850 USA

[2] Cornell Univ, Weill Inst Cell & Mol Biol, Ithaca, NY 14850 USA

来源：

NATURE CELL BIOLOGY | 2018年 / 20卷 / 04期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

DREIFUSS MUSCULAR-DYSTROPHY; LAMIN-A/C; LINC COMPLEX; ENVELOPE RUPTURE; DNA-DAMAGE; EXTRACELLULAR-MATRIX; MECHANICAL RESPONSE; MEMBRANE PROTEIN; HI-C; CHROMATIN;

D O I：

10.1038/s41556-018-0038-y

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The ability of cells to respond to mechanical forces is critical for numerous biological processes. Emerging evidence indicates that external mechanical forces trigger changes in nuclear envelope structure and composition, chromatin organization and gene expression. However, it remains unclear if these processes originate in the nucleus or are downstream of cytoplasmic signals. Here we discuss recent findings that support a direct role of the nucleus in cellular mechanosensing and highlight novel tools to study nuclear mechanotransduction.

引用

页码：373 / 381

页数：9

共 171 条

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