Multicomponent reaction in deep eutectic solvent for synthesis of substituted 1-aminoalkyl-2-naphthols

被引：43

作者：

Azizi, Najmedin ^{[1
]}

Edrisi, Mahtab ^{[1
]}

机构：

[1] Chem & Chem Engn Res Ctr Iran, POB 14335-186, Tehran, Iran

来源：

RESEARCH ON CHEMICAL INTERMEDIATES | 2017年 / 43卷 / 01期

关键词：

Betti bases; Deep eutectic solvent; Aminoalkyl naphthols; Green chemistry; HIGHLY EFFICIENT SYNTHESIS; ONE-POT; BETTI BASE; 3-COMPONENT CONDENSATION; ORGANIC-SYNTHESIS; SECONDARY-AMINES; DIETHYL-ETHER; ALDEHYDES; 2-NAPHTHOL; MIXTURES;

D O I：

10.1007/s11164-016-2628-2

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

One-pot multicomponent synthesis of Betti bases (aminoalkyl naphthols) from aldehydes, beta-naphthol, and secondary amines in deep eutectic solvent (DES) based on urea and choline chloride has been developed. A broad range of aminoalkyl naphthols can be obtained smoothly in good to excellent yield in biodegradable choline-chloride-based deep eutectic solvent, being compatible with functional groups and operationally straightforward. In addition, DES could be readily recycled at least four times without obvious loss of activity.

引用

页码：379 / 385

页数：7

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