Wilms tumor

被引：48

作者：

Paters, Luke ^{[1
]}

Melchior, Patrick ^{[2
]}

Ruebe, Christian ^{[2
]}

Cooper, Benjamin T. ^{[3
]}

McAleer, Mary Fran ^{[4
]}

Kalapurakal, John A. ^{[5
]}

Paulino, Arnold C. ^{[4
]}

机构：

[1] Univ Cincinnati, Dept Radiat Oncol, Cincinnati, OH USA

[2] Saarland Univ Hosp, Dept Radiat Oncol, Homburg, Germany

[3] NYU, Sch Med, Dept Radiat Oncol, Perlmutter Canc Ctr, New York, NY USA

[4] Univ Texas MD Anderson Canc Ctr, Dept Radiat Oncol, 1515 Holcombe Blvd,Box 97, Houston, TX 77030 USA

[5] Northwestern Univ, Dept Radiat Oncol, Chicago, IL 60611 USA

来源：

PEDIATRIC BLOOD & CANCER | 2021年 / 68卷

关键词：

chemotherapy; radiation therapy; surgery; Wilms tumor; CHILDRENS ONCOLOGY GROUP; RADIATION-THERAPY; STAGE-II; INTERNATIONAL-SOCIETY; INTERMEDIATE-RISK; NEPHRECTOMY; SURVIVAL; RELAPSE; NEPHROBLASTOMA; CHEMOTHERAPY;

D O I：

10.1002/pbc.28257

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The objectives for the treatment of Wilms tumor in both the Children's Oncology Group (COG) and the International Society of Paediatric Oncology (SIOP) have focused on improving cure rates and minimizing toxicity by limiting the use of radiation and doxorubicin. Although the timing of surgery is different in COG (upfront surgery) and SIOP (upfront chemotherapy with delayed surgery), both are effective strategies and have the same survival. Fewer patients are treated with radiotherapy in the SIOP trials but with higher doses. The prognostic significance of biological markers such as 1q gain and clinical outcomes with novel radiation techniques such as intensity modulated radiation therapy will be determined in upcoming clinical trials. A closer collaboration between COG and SIOP could help promote research and improve the clinical outcomes of children with Wilms tumor.

引用

页数：7

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