Mg-based bone implants show promising osteoinductivity and controllable degradation: A long-term study in a goat femoral condyle fracture model

被引：47

作者：

Kong, Xiangdong ^{[1
,2
]}

Wang, Lei ^{[1
]}

Li, Guoyuan ^{[1
]}

Qu, Xinhua ^{[1
]}

Niu, Jialin ^{[3
,4
]}

Tang, Tingting ^{[1
]}

Dai, Kerong ^{[1
]}

Yuan, Guangyin ^{[3
,4
]}

Hao, Yongqiang ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Shanghai Key Lab Orthopaed Implants, Shanghai Peoples Hosp 9,Dept Orthopaed, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China

[2] Tinglin Hosp Jinshan Dist, Dept Surg, 80 North Siping Rd Tinglin Town, Shanghai 201505, Peoples R China

[3] Shanghai Jiao Tong Univ, Natl Engn Res Ctr Light Alloy Net Forming, Shanghai 200240, Peoples R China

[4] Shanghai Jiao Tong Univ, Key State Lab Met Matrix Composite, Shanghai 200240, Peoples R China

来源：

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2018年 / 86卷

基金：

国家高技术研究发展计划(863计划); 中国国家自然科学基金;

关键词：

Magnesium alloy; Biodegradation; Osteoinductivity; Femoral condyle fracture model; ZN-ZR ALLOY; IN-VIVO; MECHANICAL-PROPERTIES; MAGNESIUM ALLOYS; PHOSPHATE CEMENTS; BRUSHITE; INTERFACE; EXTRUSION; CORROSION; MONETITE;

D O I：

10.1016/j.msec.2017.12.014

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

In this work, the in vivo biocompatibility and biodegradation behavior of Mg-Nd-Zn-Zr alloy (denoted as JDBM) screws were studied using a goat femoral condyle fracture model. Blood analysis indicates that the liver and kidney functions of goats were not affected by JDBM, JDBM coated with brushite (denoted as JDBM-DCPD) and PLA implants. Radiographic analysis shows that JDBM-DCPD screw has lower degradation rate than JDBM. Histological images show that compared with PLA, JDBM and JDBM-DCPD show superior effect to promote more new bone formation. JDBM-DCPD group has more new bone formation than JDBM group, indicating good osteoinductivity of DCPD coating. JDBM group show higher osteogenic factors level (BMP2, ALP and OC) in periimplant callus tissue than PLA group. Long-term (18 months) in vivo implants Micro-CT result shows that the degradation of JDBM-DCPD screw may be slower than desirable, and the thickness of DCPD coating could be further adjusted to match the degradation to the bone recovery.

引用

页码：42 / 47

页数：6

共 27 条

[1] In vivo behavior of three different injectable hydraulic calcium phosphate cements [J].