Signalling change: signal transduction through the decades

被引：49

作者：

Hynes, Nancy E. ^{[1
,2
]}

Ingham, Philip W. ^{[3
]}

Lim, Wendell A. ^{[4
]}

Marshall, Christopher J. ^{[5
]}

Massague, Joan ^{[6
,7
]}

Pawson, Tony ^{[8
,9
]}

机构：

[1] Friedrich Miescher Inst Biomed Res, CH-4058 Basel, Switzerland

[2] Univ Basel, CH-4003 Basel, Switzerland

[3] ASTAR, Inst Mol & Cell Biol, Singapore 138673, Singapore

[4] Univ Calif San Francisco, Howard Hughes Med Inst, Dept Cellular & Mol Pharmacol, San Francisco, CA 94158 USA

[5] Inst Canc Res, London SW3 6JB, England

[6] Mem Sloan Kettering Canc Ctr, Canc Biol & Genet Program, New York, NY 10065 USA

[7] Howard Hughes Med Inst, Chevy Chase, MD 20815 USA

[8] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada

[9] Univ Toronto, Dept Mol Genet, Toronto, ON M5S 1A8, Canada

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2013年 / 14卷 / 06期

基金：

加拿大健康研究院; 美国国家卫生研究院;

关键词：

NERVE GROWTH-FACTOR; TRANSFORMING GENE; PROTEIN; SIMILARITY; ONCOGENE; RECEPTOR; TYROSINE; PRODUCT; CELLS;

D O I：

10.1038/nrm3581

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The past few years have marked significant anniversaries in signal transduction, including the identification of classic growth factors and morphogens, the notion of protein modification through phosphorylation and the characterization of protein interaction domains. Here, six researchers reflect on the context in which these discoveries were made, and how our concept of cell signalling has evolved during the past three decades.

引用

页码：393 / 398

页数：6

共 14 条

[1] IDENTIFICATION OF A TRANSFORMATION-SPECIFIC ANTIGEN-INDUCED BY AN AVIAN-SARCOMA VIRUS [J].

BRUGGE, JS ;

ERIKSON, RL .

NATURE, 1977, 269 (5626) :346-348

[2] EGF and Its Receptor: Historical Perspective Introduction [J].

Cohen, Stanley .

JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA, 1997, 2 (02) :93-96

[3] AVIAN-SARCOMA VIRUS-TRANSFORMING PROTEIN, PP60SRC SHOWS PROTEIN-KINASE ACTIVITY SPECIFIC FOR TYROSINE [J].

COLLETT, MS ;

PURCHIO, AF ;

ERIKSON, RL .

NATURE, 1980, 285 (5761) :167-169

[4] CLOSE SIMILARITY OF EPIDERMAL GROWTH-FACTOR RECEPTOR AND V-ERB-B ONCOGENE PROTEIN SEQUENCES [J].

DOWNWARD, J ;

YARDEN, Y ;

MAYES, E ;

SCRACE, G ;

TOTTY, N ;

STOCKWELL, P ;

ULLRICH, A ;

SCHLESSINGER, J ;

WATERFIELD, MD .

NATURE, 1984, 307 (5951) :521-527

[5] ACTIVITY PHOSPHORYLATING TYROSINE IN POLYOMA T-ANTIGEN IMMUNOPRECIPITATES [J].

ECKHART, W ;

HUTCHINSON, MA ;

HUNTER, T .

CELL, 1979, 18 (04) :925-933

[6]

Frank-Kamenetsky Maria, 2002, J Biol, V1, P10, DOI 10.1186/1475-4924-1-10

[7] TRANSFORMING GENE-PRODUCT OF ROUS-SARCOMA VIRUS PHOSPHORYLATES TYROSINE [J].

HUNTER, T ;

SEFTON, BM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (03) :1311-1315

[8] THE NERVE GROWTH-FACTOR 35 YEARS LATER [J].

LEVIMONTALCINI, R .

SCIENCE, 1987, 237 (4819) :1154-1162

[9]

LEVINSON AD, 1980, J BIOL CHEM, V255, P1973

[10] A NOVEL VIRAL ONCOGENE WITH STRUCTURAL SIMILARITY TO PHOSPHOLIPASE-C [J].

MAYER, BJ ;

HAMAGUCHI, M ;

HANAFUSA, H .

NATURE, 1988, 332 (6161) :272-275

← 1 2 →