Primary Squamous Cell Carcinoma in the Thyroid Gland: A Population-Based Analysis Using the SEER Database

被引:32
作者
Yang, Shuwen [1 ,2 ,3 ]
Li, Cunfu [4 ]
Shi, Xiao [1 ,2 ]
Ma, Ben [1 ,2 ,3 ]
Xu, Weibo [1 ,2 ,3 ]
Jiang, Hongyi [1 ,2 ,3 ]
Liu, Wanlin [1 ,2 ]
Ji, Qinghai [1 ,2 ,3 ]
Wang, Yu [1 ,2 ,3 ]
机构
[1] Fudan Univ, Dept Head & Neck Surg, Shanghai Canc Ctr, Shanghai 200032, Peoples R China
[2] Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai 200032, Peoples R China
[3] Fudan Univ, Canc Res Inst, Shanghai Canc Ctr, Shanghai 200032, Peoples R China
[4] Weihai Cent Hosp, Dept Thyroid Surg, Weihai 264400, Peoples R China
关键词
D O I
10.1007/s00268-019-04906-2
中图分类号
R61 [外科手术学];
学科分类号
摘要
ObjectsTo evaluate prognostic factors and treatment outcomes of primary squamous cell carcinoma in thyroid (PSCCTh) over the past decades using a large national database.MethodsAll patients diagnosed with PSCCTh between 1973 and 2015 were identified with the Surveillance, Epidemiology, and End Results Program (SEER) 18-registry database. Relevant clinical data were collected, and prognostic factors of overall survival (OS) and disease-specific survival (DSS) were analyzed.ResultsThis cohort study included 242 patients, accounting for 0.12% of all primary thyroid carcinomas from 1973 to 2015 nationwide. Of the patients with PSCCTh, 75% were older than 60years at diagnosis. Patient age older than 60years (HR 2.242, 95% CI 1.367-3.676, P=0.001) and a tumor size larger than or equal to 50mm (HR 1.479, 95% CI 1.011-2.165, P=0.044) were independent negative prognostic factors. The univariate analysis suggested that the morphological subtype (OS, P=0.033; DSS, P=0.048), clinical treatment modality (OS, P<0.0001; DSS, P<0.0001), and T stage (OS, P=0.004; DSS, P=0.001) were important predictive factors for OS and DSS. In contrast, gender, race, year of diagnosis, geographic location, N stage, and M stage were not prognostic factors.ConclusionsPSCCTh is a rare malignancy with an aggressive nature and poor prognosis. Survival is predicted by the treatment modality, patient age, T stage, tumor size, and morphological subtypes. This study showed that early diagnosis and complete surgical resection plus adjuvant radiation therapy were associated with a better outcome.
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页码:1249 / 1255
页数:7
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