Chiral self-assembly of a novel (CuII/ReVII)-heterobimetallic L-Arginine complex: Crystal structure, Hirshfeld surface analysis, spectroscopic properties and biochemical studies

A novel (Cu-II/Re-VII)-heterobimetallic complex based on L-Arginine, namely trans-[Cu(L-Arg)(2)(ReO4)(2)](CuLARe), was successfully synthesized and fully characterized using X-ray structure analysis as well as (IR/UV-vis) spectroscopy, molar conductivity and (TG/DTA) thermal methods. The crystal structure determination reveals that CuLARe has a non-symmetrical atomic arrangement and features striking helical chains of {[Cu(L-Arg)(2)(ReO4)(2)]}(n), which are further assembled into a 3D-supramolecular network through multidirectional N(C, O)-H center dot center dot center dot O hydrogen bonding interactions. Analysis by Hirshfeld surface generation in combination with 2D-fingerprinting was also performed to elucidate the nature of the interactions and their contributions towards the crystal packing. Moreover, a comparative antioxidant screening of CuLARe with the free ligands as well as CuCl2 has been investigated. The results emphasize that the complexation of ligands to the metal ions plays a crucial role in the improvement of the biochemical properties of CuLARe. (C) 2019 Elsevier B.V. All rights reserved.