Pharmacogenomics in the clinic

被引：551
作者：
Relling, Mary V. [1 ]
Evans, William E. [1 ]
机构：
[1] St Jude Childrens Res Hosp, Dept Pharmaceut Sci, Memphis, TN 38105 USA
来源：
NATURE | 2015年 / 526卷 / 7573期
关键词：
IMPLEMENTATION CONSORTIUM GUIDELINES; PERSONALIZED MEDICINE; ECONOMIC-EVALUATION; DECISION-SUPPORT; RESEARCH NETWORK; GENETIC-CONTROL; DRUG-REACTIONS; GENOTYPE; CYP2D6; GENOMICS;
D O I：
10.1038/nature15817
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
After decades of discovery, inherited variations have been identified in approximately 20 genes that affect about 80 medications and are actionable in the clinic. And some somatically acquired genetic variants direct the choice of 'targeted' anticancer drugs for individual patients. Current efforts that focus on the processes required to appropriately act on pharmacogenomic variability in the clinic are moving away from discovery and towards implementation of an evidenced-based strategy for improving the use of medications, thereby providing a cornerstone for precision medicine.
引用
收藏
页码：343 / 350
页数：8
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