Pharmacogenomics in the clinic

被引：564

作者：

Relling, Mary V. ^{[1
]}

Evans, William E. ^{[1
]}

机构：

[1] St Jude Childrens Res Hosp, Dept Pharmaceut Sci, Memphis, TN 38105 USA

来源：

NATURE | 2015年 / 526卷 / 7573期

关键词：

IMPLEMENTATION CONSORTIUM GUIDELINES; PERSONALIZED MEDICINE; ECONOMIC-EVALUATION; DECISION-SUPPORT; RESEARCH NETWORK; GENETIC-CONTROL; DRUG-REACTIONS; GENOTYPE; CYP2D6; GENOMICS;

D O I：

10.1038/nature15817

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

After decades of discovery, inherited variations have been identified in approximately 20 genes that affect about 80 medications and are actionable in the clinic. And some somatically acquired genetic variants direct the choice of 'targeted' anticancer drugs for individual patients. Current efforts that focus on the processes required to appropriately act on pharmacogenomic variability in the clinic are moving away from discovery and towards implementation of an evidenced-based strategy for improving the use of medications, thereby providing a cornerstone for precision medicine.

引用

页码：343 / 350

页数：8

共 111 条

[1] Clinical practice guidelines for translating pharmacogenornic knowledge to bedside. Focus on anticancer drugs [J].

Agundez, Jose A. G. ;

Esguevillas, Gara ;

Amo, Gemma ;

Garcia-Martin, Elena .

FRONTIERS IN PHARMACOLOGY, 2014, 5

[2]

[Anonymous], 2015, Table of Pharmacogenomic Biomarkers in Drug Labels

[3]

[Anonymous], 2014 AM SOC CLIN ONC

[4]

[Anonymous], CURRENT PROTOCOLS HU

[5]

[Anonymous], CPIC GEN DRUGS

[6]

Becquemont L, 2011, PHARMACOGENOMICS, V12, P113, DOI [10.2217/pgs.10.147, 10.2217/PGS.10.147]

[7] Development and use of active clinical decision support for preemptive pharmacogenomics [J].

Bell, Gillian C. ;

Crews, Kristine R. ;

Wilkinson, Mark R. ;

Haidar, Cyrine E. ;

Hicks, J. Kevin ;

Baker, Donald K. ;

Kornegay, Nancy M. ;

Yang, Wenjian ;

Cross, Shane J. ;

Howard, Scott C. ;

Freimuth, Robert R. ;

Evans, William E. ;

Broeckel, Ulrich ;

Relling, Mary V. ;

Hoffman, James M. .

JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION, 2014, 21 (E1) :E93-E99

[8] G6PD DEFICIENCY [J].

BEUTLER, E .

BLOOD, 1994, 84 (11) :3613-3636

[9] Preemptive Genotyping for Personalized Medicine: Design of the Right Drug, Right Dose, Right Time-Using Genomic Data to Individualize Treatment Protocol [J].

Bielinski, Suzette J. ;

Olson, Janet E. ;

Pathak, Jyotishman ;

Weinshilboum, Richard M. ;

Wang, Liewei ;

Lyke, Kelly J. ;

Ryu, Euijung ;

Targonski, Paul V. ;

Van Norstrand, Michael D. ;

Hathcock, Matthew A. ;

Takahashi, Paul Y. ;

McCormick, Jennifer B. ;

Johnson, Kiley J. ;

Maschke, Karen J. ;

Vitek, Carolyn R. Rohrer ;

Ellingson, Marissa S. ;

Wieben, Eric D. ;

Farrugia, Gianrico ;

Morrisette, Jody A. ;

Kruckeberg, Keri J. ;

Bruflat, Jamie K. ;

Peterson, Lisa M. ;

Blommel, Joseph H. ;

Skierka, Jennifer M. ;

Ferber, Matthew J. ;

Black, John L. ;

Baudhuin, Linnea M. ;

Klee, Eric W. ;

Ross, Jason L. ;

Veldhuizen, Tamra L. ;

Schultz, Cloann G. ;

Caraballo, Pedro J. ;

Freimuth, Robert R. ;

Chute, Christopher G. ;

Kullo, Iftikhar J. .

MAYO CLINIC PROCEEDINGS, 2014, 89 (01) :25-33

[10] MOLECULAR MECHANISM OF SLOW ACETYLATION OF DRUGS AND CARCINOGENS IN HUMANS [J].

BLUM, M ;

DEMIERRE, A ;

GRANT, DM ;

HEIM, M ;

MEYER, UA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (12) :5237-5241

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