Neuropathic pain and reactive gliosis are reversed by dialdehydic compound in neuropathic pain rat models

被引：11

作者：

Bianco, Maria Rosaria ^{[1
]}

Cirillo, Giovanni ^{[1
]}

Petrosino, Valentina ^{[1
]}

Marcello, Lorenza ^{[1
]}

Soleti, Antonio ^{[2
]}

Merizzi, Giulia ^{[2
]}

Cavaliere, Carlo ^{[1
]}

Papa, Michele ^{[1
]}

机构：

[1] Univ Naples 2, Dipartimento Med Pubbl Clin & Preventiva, I-80138 Naples, Italy

[2] Medestea R&P, Turin, Italy

来源：

NEUROSCIENCE LETTERS | 2012年 / 530卷 / 01期

关键词：

Oxidized ATP; MED1101; Dialdehydic compounds; Spared nerve injury; Paclitaxel; Reactive astrocytosis; Synaptic homeostasis; SPINAL-CORD-INJURY; DORSAL-ROOT GANGLIA; PURINERGIC SYSTEMS; IMPROVES RECOVERY; NERVOUS-SYSTEM; MICROGLIA; ATP; EXPRESSION; RECEPTORS; ANTAGONIST;

D O I：

10.1016/j.neulet.2012.08.088

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The role of the purinergic system in the modulation of pain mechanisms suggests that it might be promising target for treating neuropathic pain. In this study we evaluated the effects of two different dialdehydic compounds: a modified stable adenosine (2-[1-(6-amminopurin-9-il)-2-osso-etossi]prop-2-enale, named MED1101), and oxidized ATP (Ox-ATP), in two different neuropathic pain rat models: the sciatic spared nerve injury (SNI) and paclitaxel evoked painful peripheral neuropathy (pPPN). Neuropathic animals were divided in groups as follows: (a) treated with intraperitoneal (i.p.) MED1101 or Ox-ATP for 21 days; (b) receiving vehicle (VEH) and (c) control (CTR) rats. The allodynic and hyperalgesic behavior was investigated by Von Frey filament test and thermal Plantar test, respectively. We evaluated by immunocytochemistry the astrocytic (GFAP) and microglial (Iba1) response on lumbar spinal cord sections. In either experimental models and using either substances, treated animals showed reduced allodynia and thermal hyperalgesia paralleled by a significant reduction of glial reaction in the spinal cord. These data prompt to hypothesize a potential role of dialdehydes as analgesic agent in chronic neuropathic pain and a possible role as anti-gliotic molecules. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：85 / 90

页数：6

共 39 条

[21] Purinergic systems, neuropathic pain and the role of microglia [J].

Inoue, Kazuhide ;

Tsuda, Makoto .

EXPERIMENTAL NEUROLOGY, 2012, 234 (02) :293-301

[22] P2X receptors as cell-surface ATP sensors in health and disease [J].

Khakh, Baljit S. ;

North, R. Alan .

NATURE, 2006, 442 (7102) :527-532

[23] Oxidized ATP inhibits T-cell-mediated autoimmunity [J].

Lang, Philipp A. ;

Merkler, Doron ;

Funkner, Pauline ;

Shaabani, Namir ;

Meryk, Andreas ;

Krings, Caroline ;

Barthuber, Carmen ;

Recher, Mike ;

Brueck, Wolfgang ;

Haeussinger, Dieter ;

Ohashi, Pamela S. ;

Lang, Karl S. .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2010, 40 (09) :2401-2408

[24] Intrathecal interleukin-10 gene therapy attenuates paclitaxel-induced mechanical allodynia and proinflammatory cytokine expression in dorsal root ganglia in rats [J].

Ledeboer, Annemarie ;

Jekich, Brian M. ;

Sloane, Evan M. ;

Mahoney, John H. ;

Langer, Stephen J. ;

Milligan, Erin D. ;

Martin, David ;

Maier, Steven F. ;

Johnson, Kirk W. ;

Leinwand, Leslie A. ;

Chavez, Raymond A. ;

Watkins, Linda R. .

BRAIN BEHAVIOR AND IMMUNITY, 2007, 21 (05) :686-698

[25] Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease [J].

Lobsiger, Christian S. ;

Cleveland, Don W. .

NATURE NEUROSCIENCE, 2007, 10 (11) :1355-1360

[26] Loss of GABAergic Interneurons in Laminae I-III of the Spinal Cord Dorsal Horn Contributes to Reduced GABAergic Tone and Neuropathic Pain after Spinal Cord Injury [J].

Meisner, Jason G. ;

Marsh, Adam D. ;

Marsh, Daniel R. .

JOURNAL OF NEUROTRAUMA, 2010, 27 (04) :729-737

[27] Pathological and protective roles of glia in chronic pain [J].

Milligan, Erin D. ;

Watkins, Linda R. .

NATURE REVIEWS NEUROSCIENCE, 2009, 10 (01) :23-36

[28] The P2X7 Receptor Drives Microglial Activation and Proliferation: A Trophic Role for P2X7R Pore [J].

Monif, Mastura ;

Reid, Christopher A. ;

Powell, Kim L. ;

Smart, Megan L. ;

Williams, David A. .

JOURNAL OF NEUROSCIENCE, 2009, 29 (12) :3781-3791

[29] The cytokine IL-1β transiently enhances P2X7 receptor expression and function in human astrocytes [J].

Narcisse, L ;

Scemes, E ;

Zhao, YM ;

Lee, SC ;

Brosnan, CF .

GLIA, 2005, 49 (02) :245-258

[30] Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury [J].

Peng, Weiguo ;

Cotrina, Maria L. ;

Han, Xiaoning ;

Yu, Hongmei ;

Bekar, Lane ;

Blum, Livnat ;

Takano, Takahiro ;

Tian, Guo-Feng ;

Goldman, Steven A. ;

Nedergaard, Maiken .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (30) :12489-12493

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