Synthesis and antioxidant activity of thymol and carvacrol based Schiff bases

被引：124
作者：
Beena [1 ]
Kumar, Deepak [1 ]
Rawat, Diwan S. [1 ]
机构：
[1] Univ Delhi, Dept Chem, Delhi 110007, India
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2013年 / 23卷 / 03期
关键词：
Antioxidant; Thymol; Carvacrol; Schiff base; DPPH; ABTS; ANTIMALARIAL ACTIVITY; IN-VITRO; ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ESSENTIAL OIL; DERIVATIVES; EXTRACTS;
D O I：
10.1016/j.bmcl.2012.12.001
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Thymol and carvacrol are well known antioxidants found in the extract of the plants of thyme species. The Schiff bases of 2-iso-propyl-5-methyl-phenol (thymol/1a), 2-tert-butyl-5-methyl-phenol (1b) and 5-iso-propyl-2-methyl-phenol (carvacrol/1c) exhibited much better antioxidant activity than thymol and carvacrol in DPPH assay. Ten compounds (4k, 4l, 4r, 5k, 5l, 5q, 5r, 6k, 6l and 6r) showed better or similar activity as compared to the reference compound ascorbic acid. Twenty-four most active compounds were also screened by ABTS method and showed 60-90% inhibition at 5 mu g/mL concentration. (c) 2012 Elsevier Ltd. All rights reserved.
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收藏
页码：641 / 645
页数：5
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