Cardiac differentiation and electrophysiology characteristics of bone marrow mesenchymal stem cells

被引：9

作者：

Liu Bo-wu ^{[1
]}

Lu An-lin ^{[1
]}

Hou Jing ^{[1
]}

Huang Wei ^{[1
]}

Li Yao ^{[1
]}

Hou Zhao-lei ^{[1
]}

Hou Hong ^{[1
]}

Da Jing ^{[1
]}

Yang Na ^{[1
]}

Ai Shi-yi ^{[1
]}

机构：

[1] Fourth Mil Med Univ Chinese Peoples Liberat Army, Dept Cardiol, Xijing Hosp, Xian 710032, Shaanxi, Peoples R China

来源：

CHINESE MEDICAL JOURNAL | 2012年 / 125卷 / 18期

关键词：

mesenchymal stem cell; differentiation; cardiac electrophysiology; ACUTE MYOCARDIAL-INFARCTION; IN-VITRO; FUNCTIONAL CARDIOMYOCYTES; PROGENITOR CELLS; HEART FUNCTION; TRANSPLANTATION; PHENOTYPE; INJECTION; REGENERATION; THERAPIES;

D O I：

10.3760/cma.j.issn.0366-6999.2012.18.022

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective To review the progress of cardiac differentiation and electrophysiological characteristics of bone marrow mesenchymal stem cells. Data sources The databases of PubMed, Springer Link, Science Direct and CNKI were retrieved for papers published from January 2000 to January 2012 with the key words of "bone marrow mesenchymal stem cells, cardiac or heart, electrophysiology or electrophysiological characteristics". Study selection The articles concerned cardiac differentiation and electrophysiological characteristics of bone marrow mesenchymal stem cells were collected. After excluding papers that study purposes are not coincident with this review or contents duplicated, 56 papers were internalized at last. Results For the treatment of myocardial infarction and myocardiac disease, the therapeutic effects of transplantation of bone marrow mesenchymal stem cells which have the ability to develop into functional myocardial cells by lots of methods have been proved by many researches. But the arrhythmogenic effect on ventricles after transplantation of bone marrow mesenchymal stem cells derived myocardial cells is still controversial in animal models. Certainly, the low differentiation efficiency and heterogeneous development of electricial function could be the most important risk for proarrhythmia. Conclusion Many studies of cardiac differentiation of bone marrow mesenchymal stem cells have paid attention to improve the cardiac differentiation rate, and the electrophysiology characteristics of the differentiated cells should be concerned for the risk for proarrhythmia as well. Chin Med J 2012;125(18):3318-3324

引用

页码：3318 / 3324

页数：7

共 55 条

[1] 5-Azacytidine induces changes in electrophysiological properties of human mesenchymal stem cells [J].