Glycinamide hydrochloride as a transient directing group: Synthesis of 2-benzylbenzaldehydes by C(sp3)-H arylation

被引：4
|
作者：
Wen, Fei [1 ]
Li, Zheng [1 ]
机构：
[1] Northwest Normal Univ, Coll Chem & Chem Engn, Lanzhou 730070, Gansu, Peoples R China
来源：
SYNTHETIC COMMUNICATIONS | 2020年 / 50卷 / 22期
基金：
中国国家自然科学基金;
关键词：
Transient directing group; 2-benzylbenzaldehyde; glycinamide hydrochloride; C(sp(3))-H arylation; 2-methylbenzaldehyde; C-H ARYLATION; BOND FORMATION; AMINO AMIDE; ALDEHYDES; GAMMA-C(SP(3))-H; C(SP(2))-H; OXIDATION; ALCOHOLS; ACIDS;
D O I：
10.1080/00397911.2020.1802759
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Glycinamide hydrochloride as an inexpensive and commercially available transient directing group for the C(sp(3))-H arylation of 2-methylbenzaldehydes is described. A series of practical 2-benzylbenzaldehydes bearing various functional groups are efficiently synthesized in satisfactory yield by this strategy. This method can also be extended to gram scale.
引用
收藏
页码：3462 / 3474
页数：13
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