Estrogen receptors and human disease: an update

被引：221

作者：

Burns, Katherine A. ^{[1
]}

Korach, Kenneth S. ^{[1
]}

机构：

[1] NIEHS, Receptor Biol Sect, Lab Reprod & Dev Toxicol, NIH, Res Triangle Pk, NC 27709 USA

来源：

ARCHIVES OF TOXICOLOGY | 2012年 / 86卷 / 10期

关键词：

Estrogen; Estrogen receptors; Human disease; Cancer; Endometriosis; Fibroids; Ovary; BETA ER-BETA; PERITONEAL-FLUID MACROPHAGES; STEROID-HORMONE RECEPTORS; ENDOMETRIAL CANCER-RISK; ALPHA GENE POLYMORPHISM; VARIANT MESSENGER-RNAS; BREAST-CANCER; OVARIAN-CANCER; TAMOXIFEN-RESISTANCE; PROSTATE-CANCER;

D O I：

10.1007/s00204-012-0868-5

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

A myriad of physiological processes in mammals are influenced by estrogens and the estrogen receptors (ERs), ER alpha and ER beta. As we reviewed previously, given the widespread role for estrogen in normal human physiology, it is not surprising that estrogen is implicated in the development or progression of a number of diseases. In this review, we are giving a 5-year update of the literature regarding the influence of estrogens on a number of human cancers (breast, ovarian, colorectal, prostate, and endometrial), endometriosis, fibroids, and cardiovascular disease. A large number of sophisticated experimental studies have provided insights into human disease, but for this review, the literature citations were limited to articles published after our previous review (Deroo and Korach in J Clin Invest 116(3):561-570, 2006) and will focus in most cases on human data and clinical trials. We will describe the influence in which estrogen's action, through one of or both of the ERs, mediates the aforementioned human disease states.

引用

页码：1491 / 1504

页数：14

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