A myocardial infarction genetic risk score is associated with markers of carotid atherosclerosis

Hamrefors V, Hedblad B, Engstrom G, Almgren P, Sjogren M, Melander O (Lund University, Malmo, Sweden). A myocardial infarction genetic risk score is associated with markers of carotid atherosclerosis. J Intern Med 2012; 271: 271281. Objective. To assess whether or not a genetic risk score thatwas previously shownto beassociated withmyocardial infarction (MI) and coronary artery disease (CAD) is also associated with markers of carotid atherosclerosis. Design. A total of 4022 middle-aged subjects from the general Swedish population were genotyped and individually assigned a genetic risk scorebasedon13 single-nucleotide polymorphisms (SNPs), previously associated with MI and CAD. The genetic score (Score-MI) was then related to carotid bulb intimamedia thickness (IMT), common carotid artery (CCA) IMT and to the occurrence of carotid plaques in the studypopulation. Results. Score-MI was associated with IMT of the bulb (P < 0.001) and the CCA (P < 0.001) in unadjusted analyses, and with IMT of the bulb after adjustment for cardiovascular risk factors (P = 0.003). The effect size of Score-MI on IMT of the bulb was similar to that of LDL cholesterol. After adjustment for cardiovascular risk factors, Score-MIwas also associated with the occurrence of carotid plaques (odds ratio per quintile of Score-MI = 1.11; 95% confidence interval 1.041.18; P = 0.001). In addition to SNPs with known effects onLDLlevels, Score-MI showednominal associations with increasing systolic blood pressure and decreasing C-reactive proteinlevels. Conclusions. This genetic risk score was independently associated with carotid bulb IMT and carotid plaques, providing evidence of an association with early markers of atherosclerosis. Thismight imply that the genetic MI risk conferred by the score is related to early atherosclerosis and that the risk score may identify at an early stage candidates at risk of developing intermediate phenotypes of atherosclerosis. Further studies should test whether or not assessing thegenetic score couldbevaluable forearly treatment decisions inthesesubjects.