Angiogenesis in chronic inflammatory liver disease

被引:180
作者
Medina, J
Arroyo, AG
Sánchez-Madrid, F
Moreno-Otero, R
机构
[1] Univ Autonoma Madrid, Hosp Princesa, Liver Unit, E-28049 Madrid, Spain
[2] Univ Autonoma Madrid, Hosp Princesa, Serv Immunol, E-28049 Madrid, Spain
关键词
D O I
10.1002/hep.20193
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Intrahepatic hypoxia may occur during the inflammatory and fibrotic processes that characterize several chronic liver diseases of viral and autoimmune origin. As a consequence, new vascular structures are formed to provide oxygen and nutrients. Angiogenesis involves a tightly regulated network of cellular and molecular mechanisms that result in the formation of functional vessels. Of particular importance are growth factors, molecules involved in matrix remodeling and cell migration, and vessel maturation-related factors. In recent years, a number of studies have examined the expression and function of many pro- and antiangiogenic molecules in the setting of nontumoral chronic liver diseases and liver regeneration. This review examines the potential pathogenetic role of angiogenesis in the context of viral hepatitis, cirrhosis, autoimmune hepatitis, primary biliary cirrhosis, and alcoholic liver disease. The future perspectives for research in this field are outlined.
引用
收藏
页码:1185 / 1195
页数:11
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